Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC61017 Lycoramine hydrobromide
石蒜胺；氢溴酸二氢加兰他敏
Lycoraminehydrobromide是一种从Lycorisradiate中分离出的加兰他敏的二氢衍生物。Lycoraminehydrobromide是一种有效的乙酰胆碱酯酶(AChE)抑制剂。
GC60966 Ketorolac D5
酮咯酸D5
An internal standard for the quantification of ketorolac
GC60965 Keto Ziprasidone KetoZiprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
GC60957 Jatrorrhizine hydroxide Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
GC60939 Iproniazid
异丙烟肼
Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
GC60938 Iprindole
伊普吲哚
Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
GC60935 Indomethacin sodium hydrate
吲哚美辛钠盐三水合物; Indometacin sodium hydrate
A non-selective COX inhibitor
GC60926 Ibuprofen impurity 1
布洛芬杂质
Ibuprofenimpurity1是Ibuprofen的杂质。Ibuprofen是COX-1和COX-2的抑制剂，IC50值分别为13μM和370μM，具有抗炎的活性。
GC60924 Hydroxyzine D8
安泰乐D8
An internal standard for the quantification of hydroxyzine
GC60917 Hydroxyamine hydrochloride
羟胺盐酸盐
Hydroxylammonium chloride (Hydroxylamine hydrochloride) is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the nitrification and in the anammox.
GC60915 Hydroxy ziprasidone
齐拉西酮羟基化杂质
Hydroxyziprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
GC60913 Huperzine C
石杉碱丙
HuperzineC是从Huperziaserrate中分离的一种生物碱。HuperzineC是一种乙酰胆碱酯酶(AChE)抑制剂，其IC50值为0.6μM。HuperzineC可用于阿尔茨海默症的研究。
GC60890 Guvacine
去甲槟榔次碱
An inhibitor of GABA uptake
GC60886 GSK356278 A selective PDE4 inhbitor
GC60875 GKT136901
NOX Inhibitor IV
A dual inhibitor of NOX1 and NOX4
GC60866 Gap 26 TFA Gap 26, a connexin mimetic peptide that composeds of residue no. 63-75 of the extracellular loop 1 of connexin 43 (Cx43), is a gap junction inhibitor. Gap 26 blocks photoliberating inositol-1,4,5-trisphosphate triggers ATP release.
GC60862 GABAA receptor agent 1
2-(4-氯苯基)-6-硝基-1H-苯并[D]咪唑
GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
GC60846 Flesinoxan
氟辛克生
Flesinoxan是一种降压剂，是一种有效的，高亲和力的选择性的5-羟色胺1A(5-HT1A)受体激动剂，EC50值为24nM。Flesinoxan还具有有效的抗焦虑/抗抑郁作用。
GC60791 Doxepin D3 Hydrochloride
盐酸多塞平 D3
DoxepinD3Hydrochloride是DoxepinHydrochloride的氘代物。Doxepinhydrochloride是一种口服活性的三环抗抑郁药。Doxepinhydrochloride是一种有效的选择性组胺受体H1拮抗剂。Doxepinhydrochloride也是一种有效的CYP450抑制剂，并显着抑制CYP4502C19和CYP4501A2。
GC60774 Dihydro Donepezil
盐酸多奈哌齐二氢杂质,Dihydro E2020
DihydroDonepezil(DihydroE2020)是Donepezil的代谢产物。Donepezil是一种有效的特异性AChE抑制剂，对bAChE和hAChE的IC50分别为8.12nM和11.6nM。
GC60758 Deschloroclozapine
氯氮平杂质
Deschloroclozapine是一种高亲和力、选择性且代谢稳定的毒蕈碱DREADD激动剂，Deschloroclozapine能快速穿透血脑屏障，有效激活兴奋性hM3Dq和抑制性hM4Di DREADD受体。
GC60740 Dapoxetine-D7 hydrochloride
LY-210448-d7 hydrochloride
Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。
GC60723 COR659 COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。
GC60709 Cinnarizine D8
桂利嗪 D8
An internal standard for the quantification of cinnarizine
GC60691 Cetirizine Impurity C
西替利嗪杂质C
CetirizineImpurityC是Cetirizine的一种杂质。Cetirizine是羟嗪的羧化代谢物，是第二代抗组胺剂。Cetirizine是一种特异的、具有口服活性的H1受体(histamineH1-receptor)的长效拮抗剂。
GC60662 Brexpiprazole S-oxide
依匹哌唑硫氧化杂质,DM-3411

BrexpiprazoleS-oxide(DM-3411)是Brexpiprazole的主要代谢产物，并通过细胞色素P4503A4(CYP3A4)代谢。Brexpiprazole是一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12nM和0.3nM。Brexpiprazole也是5-HT2A受体的拮抗剂，Ki为0.47nM。
GC60641 Betahistine mesylate
甲磺酸倍他司汀
Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.
GC60630 Befiradol hydrochloride
NLX-112 hydrochloride; F 13640 hydrochloride
Befiradolhydrochloride(NLX-112hydrochloride)是选择性的5-羟色胺1A(5-HT)1A受体激动剂。
GC60596 Arecaidine
槟榔次碱
Arecaidine，一种吡啶生物碱，是一种有效的GABA吸收抑制剂。Arecaidine是H+偶联的氨基酸转运蛋白1(PAT1，SLC36A1)的底物，竞争性抑制L-脯氨酸的摄取。
GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.
GC60563 Acrivastine D7
阿伐斯汀-D7,BW825C D7
AcrivastineD7(BW825CD7)是Acrivastine的一种氘代化合物。Acrivastine是一种短效的histamine1受体拮抗剂。
GC60549 ABT-418 hydrochloride
3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
ABT-418hydrochloride是一种高效、选择性的nAChRs激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride激活胆碱能通道，可用于阿尔茨海默病的研究。
GC60527 5,7-Dimethoxyluteolin
5,7-二甲氧基木犀草素
5,7-Dimethoxyluteolin，一种5,7-二甲基木犀草素衍生物，是一种多巴胺转运蛋白(DAT)活化剂，EC50值为3.417μM。
GC60523 4-Methylamino antipyrine hydrochloride
安乃近杂质C
An active metabolite of metamizole
GC60519 4-Hydroxyderricin
4-羟基德里辛
4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
GC60517 4-Hydroxyatomoxetine
4'-羟基托莫西汀
A metabolite of atomoxetine
GC60506 3-O-Methyldopa D3
3-甲氧基-L-酪氨酸-D3,3-Methoxy-L-tyrosine-d3; 3-O-Methyl-L-DOPA-d3
3-O-MethyldopaD3(3-Methoxy-L-tyrosineD3)是3-O-Methyldopa的氘代物。3-O-Methyldopa是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。
GC60505 3-O-Methyldopa
(S)-2-氨基-3-(4-羟基-3-甲氧苯基)丙酸,3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA
3-O-Methyldopa(3-Methoxy-L-tyrosine)是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。
GC60499 3-Hydroxy agomelatine
阿戈美拉汀杂质
3-Hydroxyagomelatine是Agomelatine的代谢产物。3-Hydroxyagomelatine是5-HT2C受体拮抗剂，IC50为3.2μM，Ki为1.8μM。
GC60447 1-Hydroxy-ibuprofen
1-羟基异丁基苯基-1'-甲基丙酸
1-hydroxy Ibuprofen 是非甾体类抗炎药 (NSAID) 和非选择性 COX 抑制剂布洛芬的代谢物。
GC60424 (S)-Venlafaxine
文拉法辛S-异构体
(S)-Venlafaxine是Venlafaxine的S构型化合物。Venlafaxine是口服有效的5-羟色胺(5-HT)/去甲肾上腺素(NE)重摄取的双重抑制剂。Venlafaxine具有抗抑郁作用。
GC60423 (S)-UFR2709 hydrochloride (S)-UFR2709(hydrochloride)是一种竞争性的nAChR拮抗剂，并显示出较强的亲和力，对α4β2nAChR的亲和力比对α7nAChR的高。(S)-UFR2709(hydrochloride)在偏好酒精的老鼠中减少焦虑，并且可以减少其酒精摄入和对酒精偏好。(S)-UFR2709(hydrochloride)是抗焦虑试剂，可用于研究尼古丁成瘾。
GC60413 (Rac)-NMDAR antagonist 1 (Rac)-NMDARantagonist1是NMDARantagonist1的消旋体。NMDARantagonist1是一种有效且口服生物可利用的，NR2B选择性的NMDAR拮抗剂。
GC60394 (±)-Duloxetine hydrochloride
(Rac)-Duloxetine hydrochloride
(±)-Duloxetine((Rac)-Duloxetine)hydrochloride是Duloxetinehydrochloride的外消旋体。Duloxetinehydrochloride是一种5-羟色胺去甲肾上腺素再摄取抑制剂，可用于糖尿病性神经痛和纤维肌痛以及抑郁症的研究。
GC46243 24-dehydro Cholesterol-d6
Desmosterol-d6
An internal standard for the quantification of 24-dehydro cholesterol
GC46242 7-dehydro Cholesterol-d7
7-去氢胆固醇 d7
An internal standard for the quantification of 7-dehydro cholesterol
GC46241 7-keto Cholesterol-d7
7-酮基胆固醇-D7,7-oxo Cholesterol-d7
An internal standard for the quantification of 7-keto cholesterol
GC60383 Vomifoliol
吐叶醇
Vomifoliol是一种与脱落酸(ABA)有关的化合物，具有修饰的2,4-戊二烯侧链，其活性与ABA的活性相当。Vomifoliol表现出抗乙酰胆碱酯酶(antiacetylcholinesterase)活性和中等抗利什曼虫(antileishmanial)活性。
GC60354 Tat-NR2Baa Tat-NR2BAA 是 Tat-NR2B9c 的对照肽 (control peptide)，没有活性。Tat-NR2BAA 的序列与 Tat-NR2B9c 相似，但在 COOH 末端 tSXV 基序中有一个双点突变，这使得它无法结合 PSD-95。Tat-NR2B9c 是一种可通透细胞膜的多肽，破坏 PSD-95/NMDAR 的结合。
GC60345 Sphondin
牛防风素
Sphondin可从Heracleumlaciniatum中分离，对IL-1β诱导的A549细胞中COX-2蛋白和PGE2释放水平的升高具有抑制作用。