Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 ?M for human COX-1 and COX-2, respectively).1 It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes.2 Indomethacin reduces ocular inflammation induced by bovine serum in rabbits.3 It also reduces paw edema in a rat model of carrageenan-induced inflammation.4
1.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim. Biophys. Acta1209(1)130-139(1994) 2.D'Arcy, P.F., and Howard, E.M.A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryoBr. J. Pharmacol. Chemother.29(3)378-387(1967) 3.Hanna, C., and Keatts, H.C.Indomethacin in ocular inflammation in rabbitsArch. Opthalmol.77(4)554-558(1967) 4.Winter, C.A., Risley, E.A., and Silber, R.H.Antiinflammatory activity of indomethacin and plasma corticosterone in ratsJ. Pharmacol. Exp. Ther.162(1)196-201(1968)