Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC31269 Cipralisant (GT-2331)

GT-2331
Cipralisant (GT-2331) (GT-2331) 是一种具有口服活性、低毒、强效、选择性、高亲和力组胺 H3 受体的体内完全拮抗剂，在体外是一种激动剂，对组胺 H3 受体的 pKi 为 9.9，大鼠组胺 H3 受体的 Ki 为 0.47 nM。
GC68869 Cipralisant maleate

GT-2331 maleate
Cipralisant (GT-2331) (maleate) 在体内是一种具有口服活性、低毒、有效、选择性、高亲和力的 histamine H3 receptor 的拮抗剂，在体外是 histamine H3 receptor 的激动剂，对于 histamine H3 receptor，其 pKi 为 9.9，对大鼠 histamine H3 receptor 的Ki为 0.47 nM。Cipralisant (maleate) 有研究注意缺陷多动障碍的潜力。
GC12924 Ciproxifan

FUB-359
A histamine H₃ receptor antagonist
GC15847 Ciproxifan maleate

环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐,FUB 359 maleate
A histamine H₃ receptor antagonist
GC14414 CIQ

(3-氯苯基)[3,4-二氢-6,7-二甲氧基-1-[(4-甲氧基苯氧基)甲基]-2(1H)-异喹啉基]甲酮
A subunit-selective NMDA receptor potentiator
GC31120 Cirsimaritin

蓟黄素
Cirsimaritin是一种存在于植物中的二甲氧基黄酮，具有抗癌潜力，并显示出显著的抗菌、抗氧化、解痉作用，同时还可抑制环氧合酶-1。
GC40834 cis-Entacapone

(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
A metabolite of entacapone
GC10260 cis-Flupenthixol (hydrochloride)

顺式-(Z)-氟哌噻吨二盐酸盐,cis-Flupentixol
A typical antipsychotic
GC38753 cis-Urocanic acid

顺式-尿刊酸; (Z)-Urocanic acid; cis-UCA
cis-Urocanic acid 是一种 5-HT2A 受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合，Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。
GC13533 Cisapride

西沙比利; R 51619; (±)-Cisaprid
A 5-HT₄ receptor agonist
GC25259 Cisapride hydrate

Propulsid, Alimix, Propulsin, Enteropride, Kinestase
Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
GC12226 Cisatracurium Besylate

顺苯磺酸阿曲库铵; 51W89
A competitive antagonist of nAChRs and non-depolarizing muscle relaxant
GC50195 Citalopram - d4 hydrobromide

Bonitrile-d4, Nitalapram-d4, Prepram-d4
An internal standard for the quantification of citalopram
GC14035 Citalopram hydrobromide

氢溴酸西酞普兰; (±)-Citalopram hydrobromide; Lu 10-171
A selective serotonin reuptake inhibitor
GC47096 Citrinin-13C13

(-)-Citrinin-13C13, CTN-13C13
A neuropeptide with diverse biological activities
GC43274 Citromycetin

柠檬菌素
A fungal metabolite
GC18728 CJ-13610 An inhibitor of 5-LO
GC47097 CJC-1295

Modified GRF (1-29), CJC-1295-no DAC, GHRH (1-29)-NH2
A synthetic peptide derivative of GHRH
GC92120 CJC-1295 (acetate)

Modified GRF (1-29); CJC-1295-no DAC; GHRH (1-29)-NH₂
CJC-1295 (acetate)是生长激素释放激素（GHRH）的合成肽衍生物。
GC73211 CK156 CK156是一种高度选择性的死亡相关蛋白激酶（DAPK）抑制剂，在DRAK1、CK2a1和CK2a2的DRAK1 NanoBRET检测中，IC50分别为182 nM、34μM和39μM。
GC49556 Cl-Necrostatin-1

7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f
A RIPK1 inhibitor
GC61887 Cl-NQTrp Cl-NQTrp 显著破坏 tau 衍生的 PHF6 (VQIVYK) 肽和全长 tau 蛋白的预制纤维聚集物。
GC31418 Clebopride malate

苹果酸氯波必利
Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting.
GC14892 Clemastine Fumarate

富马酸氯马斯汀; HS-592 fumarate; Meclastine fumarate
A histamine H₁ receptor antagonist
GC12444 Clemizole

吡咯咪唑
An antihistamine and TRPC5 channel blocker
GC17701 Clemizole hydrochloride

盐酸克立咪唑
An antihistamine and TRPC5 channel blocker
GC31048 Clidinium bromide (Ro 2-3773)

克利溴铵,Ro 2-3773
A muscarinic receptor antagonist
GC10490 Clobenpropit dihydrobromide

丙酸倍氯松二溴酸盐溶液,1000PPM,VUF 9153
A selective histamine H₃ receptor antagonist
GC31037 Clocapramine (Clocarpramine)

Clocarpramine; 3-Chlorocarpipramine

Clocapramine是多巴胺D2和5-HT2A受体拮抗剂。
GC38758 Clomethiazole

氯美噻唑
Chlormethiazole 是一种有效的口服 GABAA 激动剂。 Chlormethiazole 还可以抑制人肝微粒体中的细胞色素 P450 亚型: CYP2A6 和 CYP2E1。Chlormethiazole 有抗惊厥作用，具有治疗惊厥性癫痫的潜力。
GC30375 Clomipramine D3

Chlorimipramine-d3; G-34586-d3; NSC-169865-d3
An Analytical Reference Standard
GC15107 Clomipramine HCl

盐酸氯米帕明; Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride
A tricyclic antidepressant
GC47101 Clomipramine-d3 (hydrochloride)

盐酸氯米帕明-D3,Chlorimipramine-d3 hydrochloride; G-34586-d3 hydrochloride; NSC-169865-d3 hydrochloride
An Analytical Reference Standard
GC47103 Clonidine-d4 (hydrochloride)

可乐定 d4 (盐酸盐)
An internal standard for the quantification of clonidine
GC15964 Clopidogrel hydrogen sulfate

硫酸氢氯吡格雷; (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate
A prodrug form of a P2Y₁₂ antagonist
GC47106 Clopyralid

二氯吡啶酸
An herbicide
GC14122 Clorgyline (hydrochloride)

盐酸氯吉林
Clorgyline (hydrochloride)是一种不可逆、强效和选择性单胺氧化酶（MAO）A 抑制剂，对MAO-A和MAO-B的K_i值分别为0.054和58μM，IC₅₀值分别为 0.0012和1.9μM。
GC17760 Clozapine

氯氮平; HF 1854
An atypical antipsychotic
GC43283 Clozapine (hydrochloride) An atypical antipsychotic
GC50193 Clozapine - d8

HF 1854-d8
Clozapine - d8 (HF 1854-d8) 是氘标记的氯氮平。
GC10822 Clozapine N-oxide (CNO)

氯氮平N-氧化物
Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。
GC43284 Clozapine N-oxide (hydrochloride)

CNO

A metabolite of clozapine and muscarinic DREADD agonist
GC47110 Clozapine-d4

氯氮平-D4,HF 1854-d4
An internal standard for the quantification of clozapine
GC13290 CMPDA A positive allosteric modulator of GluA2
GC50306 CMPI hydrochloride Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
GC40632 CMS121 CMS121是一种口服有效的乙酰辅酶A羧化酶1（ACC1）抑制剂。
GC11799 CNQX

6-氰基-7-硝基喹喔啉-2,3-二酮,FG9065
CNQX是一种有效的竞争性AMPA /海藻酸酯受体(AMPA/kainate receptor)拮抗剂,IC50 分别为0.3µM和1.5µM。
GC32553 CNS-5161 hydrochloride (CNS 5161A)

CNS 5161A
CNS-5161 hydrochloride (CNS 5161A) 是一种新型 NMDA 离子通道拮抗剂，可与 NMDA 受体/离子通道位点相互作用，对谷氨酸的作用产生非竞争性阻断。
GC47116 Coenzyme Q10-d6

辅酶Q10-D6,CoQ10-d6; Ubiquinone-10-d6
An internal standard for the quantification of CoQ₁₀
GP10010 COG 133

Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu

A peptide fragment of ApoE and an α7 nAChR antagonist