C22 Glucosylceramide-d4 is intended for use as an internal standard for the quantification of C22 glucosylceramide by GC- or LC-MS. C22 Glucosylceramide is an endogenous glucosylceramide.1,2,3 Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.3 It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.2 In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.1 [Matreya, LLC.]
1.Bergman, B.C., Brozinick, J.T., Strauss, A., et al.Serum sphingolipids: Relationships to insulin sensitivity and changes with exercise in humansAm. J. Physiol. Endocrinol. Metab.309(4)E398-E408(2015) 2.JovÉ, M., Ayala, V., RamÍrez-NÚÑez, O., et al.Specific lipidome signatures in central nervous system from methionine-restricted miceJ. Proteome Res.12(6)2679-2689(2013) 3.Ee, S.-M., Lo, Y.-L., Shui, G., et al.Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognitionMol. Neurobiol.50(1)60-75(2014)