Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC43768 Glucocerebrosides (Gaucher's spleen)

Ganglioside GL1a, Gaucher cerebroside, GluCers (Gaucher's spleen), Glucocerebrosides, Glucosylceramides (Gaucher's spleen)
A sphingolipid
GC92133 Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)

Gastric Inhibitory Peptide (1-42); GIP (1-42)
Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)是一种内源性42个氨基酸的肽肠促胰岛素激素，可诱导胰岛素分泌。
GC52493 Glucosylceramide (bovine buttermilk)

GluCers (buttermilk), Glucocerebrosides (buttermilk)
A sphingolipid
GC69175 GluN2B-NMDAR antagonist-1 GluN2B-NMDAR antagonist-1 是一种具有口服活性的 GluN2B-NMDAR 拮抗剂。GluN2B-NMDAR antagonist-1 具有神经保护活性。 GluN2B-NMDAR antagonist-1 可用于缺血性损伤研究。
GC30892 Glutaminyl Cyclase Inhibitor 1 GlutaminylCyclaseInhibitor1是谷氨酰胺酰基环化酶(glutaminylcyclase)抑制剂，IC50值为0.5μM。
GC31110 Glutaminyl Cyclase Inhibitor 2 GlutaminylCyclaseInhibitor2是谷氨酰胺酰基环化酶(glutaminylcyclase)抑制剂，IC50值为1.23μM。
GC36156 Glutaminyl Cyclase Inhibitor 3 Glutaminyl Cyclase Inhibitor 3 (compound 212 ) 是一种具有抗阿尔兹海默症作用的化合物，是有效的人谷氨酰胺酰环化酶 (GC) 的抑制剂，其 IC50 值为 4.5 nM。Glutaminyl Cyclase-IN-1 (compound 212) 可显著降低大脑Aβ的浓度，并恢复认知功能。
GC43774 Glycerophospho-N-Arachidonoyl Ethanolamine

Glycerophosphoanandamide, GlycerophosphoArachidonoyl Ethanolamide, GPNArE
Precursor of anandamide
GC49273 Glycerophosphorylethanolamine (sodium salt)

Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine
An active metabolite of phosphatidylethanolamine
GC49418 Glycine-13C

甘氨酸 2-13C
An internal standard for the quantification of glycine
GC64245 Glycine-13C2

甘氨酸 13C2

Glycine-13C2 是带有 13C 标记的 Glycine。Glycine 是中枢神经系统的一种抑制性神经递质，同时也是 glutamate 的一种联合激动剂，有促进谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受体兴奋的潜能。
GC64249 Glycine-15N

甘氨酸 15N
Glycine-15N 是一种 15N 标记的 Glycine。Glycine 是中枢神经系统的一种抑制性神经递质，同时也是 glutamate 的一种联合激动剂，有促进谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受体兴奋的潜能。
GC49732 Glycine-d5

甘氨酸-d5
An internal standard for the quantification of glycine
GC15029 Glycopyrrolate

格隆溴铵; Glycopyrronium bromide; Glycopyrrolate bromide
A muscarinic acetylcholine receptor antagonist
GC47413 Glycoursodeoxycholic Acid-d4

甘氨熊去氧胆酸 d4
An internal standard for the quantification of glycoursodeoxycholic acid
GC49509 Glycyl-L-Glutamine (hydrate)

甘氨酰-L-谷氨酰胺
A dipeptide fragment of β-endorphin
GC14121 GLYX 13

雷帕替奈; GLYX-13
A partial agonist of the NMDA receptor
GC31270 GNE 0723
GNE0723是一种可透过血脑屏障的NMDAR的正向调节剂，对GluN2A的EC50值为21nM，对GluN2C和GluN2D的EC50值分别为7.4和6.2μM。
GC31076 GNE 5729 GNE5729是一种可透过血脑屏障的NMDAR的正向调节剂，对GluN2A的EC50值为37nM，对GluN2C和GluN2D的EC50值分别为4.7和9.5μM。
GC50433 GNE 9278 Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
GC43781 GnRH (free acid; trifluoroacetate salt)

Gonadorelin, Gonadotropin-releasing Hormone, LHRH
A biologically inactive form of GnRH
GC43782 GnRH II (trifluoroacetate salt)

Gonadotropin-releasing Hormone II, LHRH II
A GnRHR agonist
GC71095 GPR139 agonist-2 GPR139 agonist-2（化合物20a）是一种强效的GPR139激动剂，EC50为24.7nM。
GC16903 GR 103691 A dopamine D₃ receptor antagonist
GC11624 GR 113808 GR 113808是一种有效和选择性的5-HT4受体拮抗剂，pK_b=8.8。
GC61464 GR 125743 GR125743是一种选择性的5-HT1B/1D受体拮抗剂，与野生型的人h5-HT1B和5-HT1D结合的pKi分别为8.85和8.31。GR125743可用于帕金森病和心血管疾病的研究。
GC16408 GR 159897

({1-[2-(5-氟-1H-吲哚-3-基)乙基]-4-甲氧基-4-哌啶基}甲基)(苯基)锍醇
A nonpeptide NK₂ receptor antagonist
GC50069 GR 203040 Potent and selective NK1 antagonist
GC74636 GR 55562 hydrochloride GR 55562 hydrochloride是一种选择性5-HT1B受体拮抗剂。
GC18080 GR 73632 GR 73632 是一种新型速激肽神经激肽 1 (NK-1) 受体激动剂。
GC18149 GR 82334 GR 82334 是一种有效且特异性的可逆速激肽 NK1 受体拮抗剂。
GC12398 Granisetron

格拉司琼; BRL 43694
Granisetron (BRL 43694) 是一种血清素 5-HT3 受体拮抗剂，用作止吐剂，用于治疗化疗后的恶心和呕吐。
GC16029 Granisetron HCl

盐酸格拉司琼; BRL 43694A
A 5-HT₃ receptor antagonist with antiemetic activity
GC47414 Granisetron-d3

格拉司琼-D3
An internal standard for the quantification of granisetron
GC18788 Graphislactone A An antioxidant
GC15832 GSK 264220A An endothelial lipase inhibitor
GC14593 GSK 789472 hydrochloride dopamine D3 receptor antagonist and D2 partial agonist
GC32764 GSK-LSD1 Dihydrochloride An LSD1 inhibitor
GC19176 GSK163090 GSK163090 是一种有效的、选择性的和具有口服活性的 5-HT1A/1B/1D 受体拮抗剂，pKi 值分别为 9.4/8.5/9.7。
GC19178 GSK189254A

GSK189254
A histamine H₃ receptor antagonist
GC60886 GSK356278 A selective PDE4 inhbitor
GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
GC30241 GSK598809
GSK598809是多巴胺D3受体(DRD3)的选择性拮抗剂，其pKi值为8.9。
GC16180 GT 2016 A histamine H₃ receptor antagonist
GP10115 GTP-Binding Protein Fragment, G alpha

H2N-Cys-Gly-Ala-Gly-Glu-Ser-Gly-Lys-Ser-Thr-Ile-Val-Lys-Gln-Met-Lys-OH

Hydrolyzes GTP to GDP
GC10913 GTS 21 dihydrochloride

(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐,DMXB-A; DMBX-anabaseine
An agonist of α7-containing nAChRs
GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.
GC47416 Guanfacine-13C,15N3

胍法辛-13C-15N3
An internal standard for the quantification of guanfacine
GC43797 Guanosine 5'-monophosphate (sodium salt)

GMP, 5'-Guanylic Acid, NSC 20265
Guanosine 5'-monophosphate is a nucleotide used in the synthesis of RNA.
GC60890 Guvacine

去甲槟榔次碱
An inhibitor of GABA uptake