GPCR/G protein

GPCR/G protein(G 蛋白偶联受体/G 蛋白)

研究方向

GPCR/G protein 相关产品(3377)

GC25728 PF-4136309
CAS: 857679-55-1
PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.
GC25756 Pirenperone
CAS: 75444-65-4
Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
GC25786 Propafenone
CAS: 54063-53-5
Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.
GC25898 SB 200646
CAS: 143797-63-1
SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
GC26002 Trazodone
CAS: 19794-93-5
纯度: >98.00%
Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
GC26016 TSHR antagonist S37
CAS: 1217616-61-9
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
GC26027 V-0219
CAS: 878453-71-5
V-0219 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), can be used for obesity-associated diabetes research.
GC26069 WAY-639889
CAS: 432506-24-6
WAY-639889 is a bioactive compound relative to neuropeptide Y-5.
GC26144 Menthol
CAS: 1490-04-6
Menthol 是个天然的止痛剂。Menthol 通过抑制神经元细胞膜的 Ca ++ 电流，刺激冷感受器，从而产生凉的感觉。
GC30008 Ceruletide (Caerulein)
CAS: 17650-98-5
纯度: >99.50%
Ceruletide 作为一种十肽和一种有效的胆囊收缩剂，对人类和动物的胆囊肌肉和胆管具有直接的痉挛作用。
GC30058 GLP-1(7-37)
CAS: 106612-94-6
纯度: >99.50%
GLP-1(7-37)是一种截短的胰高血糖素样肽，对GLP-1受体的EC 50 值为0.9 ± 0.1nM。
GC30068 Taprenepag (CP-544326)
CAS: 752187-80-7
纯度: >99.50%
A potent EP 2 receptor agonist
GC30092 Salmeterol (GR33343X)
CAS: 89365-50-4
纯度: >99.50%
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
GC30095 SB-423562
CAS: 351490-27-2
纯度: >99.50%
SB-423562是一种短效的(CaR)拮抗剂。
GC30104 Fezolinetant (ESN-364)
CAS: 1629229-37-3
纯度: >98.00%
Fezolinetant (ESN-364) 是一种神经激肽 3 受体 (NK3R) 的拮抗剂，用于治疗更年期潮热。
GC30188 Dapiprazole hydrochloride
CAS: 72822-13-0
纯度: >99.50%
An α-adrenergic receptor antagonist
GC30194 JNJ-10229570
CAS: 524923-88-4
纯度: >98.00%
JNJ-10229570 (UNII-N9IX402L35) is a potent MC1R and MC5R antagonist.
GC30198 Dolasetron Mesylate hydrate
CAS: 878143-33-0
纯度: >99.00%
A 5-HT 3 receptor antagonist
GC30206 Roluperidone (CYR-101)
CAS: 359625-79-9
纯度: >99.50%
A dual antagonist of 5-HT 2A and σ 2 receptors
GC30224 FPTQ
CAS: 864863-72-9
纯度: >99.50%
FPTQ是mGluR1拮抗剂，在人和老鼠上IC50是6nM和4nM
GC30254 HAEGTFT
CAS: 926018-95-3
纯度: >99.00%
HAEGTFT是GLP-1多肽N-端的1-7残基。
GC30273 Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide)
CAS: 960151-65-9
纯度: >99.50%
Tedatioxetine (Lu AA24530) hydrobromide 可作为 5-HT2A、5-HT2C、5-HT3 和 α；1A-肾上腺素受体拮抗剂，可作为 5-羟色胺和去甲肾上腺素 (NE) 的首选三重再摄取抑制剂 (TRI)。
GC30280 Chlorpromazine D6 hydrochloride
CAS: 1228182-46-4
纯度: >99.50%
Chlorpromazine D6 hydrochloride是 Chlorpromazine 的氘代物，可被用于 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
GC30299 GSK726701A
CAS: 945721-87-9
纯度: >98.50%
GSK726701A是前列腺素E2受体4(EP4)的部分激动剂，pEC50为7.4。

分类产品列表
货号	产品名称	CAS号	纯度
GC25728	PF-4136309	857679-55-1	-
GC25728	PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.
GC25756	Pirenperone	75444-65-4	-
GC25756	Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
GC25786	Propafenone	54063-53-5	-
GC25786	Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.
GC25898	SB 200646	143797-63-1	-
GC25898	SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
GC26002	Trazodone	19794-93-5	>98.00%
GC26002	Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
GC26016	TSHR antagonist S37	1217616-61-9	-
GC26016	TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
GC26027	V-0219	878453-71-5	-
GC26027	V-0219 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), can be used for obesity-associated diabetes research.
GC26069	WAY-639889	432506-24-6	-
GC26069	WAY-639889 is a bioactive compound relative to neuropeptide Y-5.
GC26144	Menthol	1490-04-6	-
GC26144	Menthol 是个天然的止痛剂。Menthol 通过抑制神经元细胞膜的 Ca ++ 电流，刺激冷感受器，从而产生凉的感觉。
GC30008	Ceruletide (Caerulein)	17650-98-5	>99.50%
GC30008	Ceruletide 作为一种十肽和一种有效的胆囊收缩剂，对人类和动物的胆囊肌肉和胆管具有直接的痉挛作用。
GC30058	GLP-1(7-37)	106612-94-6	>99.50%
GC30058	GLP-1(7-37)是一种截短的胰高血糖素样肽，对GLP-1受体的EC 50 值为0.9 ± 0.1nM。
GC30068	Taprenepag (CP-544326)	752187-80-7	>99.50%
GC30068	A potent EP 2 receptor agonist
GC30092	Salmeterol (GR33343X)	89365-50-4	>99.50%
GC30092	Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
GC30095	SB-423562	351490-27-2	>99.50%
GC30095	SB-423562是一种短效的(CaR)拮抗剂。
GC30104	Fezolinetant (ESN-364)	1629229-37-3	>98.00%
GC30104	Fezolinetant (ESN-364) 是一种神经激肽 3 受体 (NK3R) 的拮抗剂，用于治疗更年期潮热。
GC30188	Dapiprazole hydrochloride	72822-13-0	>99.50%
GC30188	An α-adrenergic receptor antagonist
GC30194	JNJ-10229570	524923-88-4	>98.00%
GC30194	JNJ-10229570 (UNII-N9IX402L35) is a potent MC1R and MC5R antagonist.
GC30198	Dolasetron Mesylate hydrate	878143-33-0	>99.00%
GC30198	A 5-HT 3 receptor antagonist
GC30206	Roluperidone (CYR-101)	359625-79-9	>99.50%
GC30206	A dual antagonist of 5-HT 2A and σ 2 receptors
GC30224	FPTQ	864863-72-9	>99.50%
GC30224	FPTQ是mGluR1拮抗剂，在人和老鼠上IC50是6nM和4nM
GC30254	HAEGTFT	926018-95-3	>99.00%
GC30254	HAEGTFT是GLP-1多肽N-端的1-7残基。
GC30273	Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide)	960151-65-9	>99.50%
GC30273	Tedatioxetine (Lu AA24530) hydrobromide 可作为 5-HT2A、5-HT2C、5-HT3 和 α；1A-肾上腺素受体拮抗剂，可作为 5-羟色胺和去甲肾上腺素 (NE) 的首选三重再摄取抑制剂 (TRI)。
GC30280	Chlorpromazine D6 hydrochloride	1228182-46-4	>99.50%
GC30280	Chlorpromazine D6 hydrochloride是 Chlorpromazine 的氘代物，可被用于 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
GC30299	GSK726701A	945721-87-9	>98.50%
GC30299	GSK726701A是前列腺素E2受体4(EP4)的部分激动剂，pEC50为7.4。