GlpBio

GPCR19

GPCR19(G 蛋白偶联受体19)

GPCR19 is a G protein-coupled receptor for bile acid. Activation of this receptor induces its internalization and the production of intreacelluar cAMP. It is Involved in the suppression of macrophage function and regulation of energy homeostasis.

GPCR19 相关产品(12)

  • GC16363 structure
    GC16363TGR5 Receptor Agonist
    CAS: 1197300-24-5
    纯度: >99.50%

    A TGR5 agonist

  • GC30565 structure
    GC30565BAR502
    CAS: 1612191-86-2
    纯度: >98.00%

    A dual agonist of GP-BAR1 and FXR

  • GC31370 structure
    GC31370SB756050
    CAS: 447410-57-3
    纯度: >99.00%

    A TGR5 agonist

  • GC32742 structure
    GC32742INT-767
    CAS: 1000403-03-1
    纯度: >98.00%

    INT-767是一种强效的法尼醇X受体（FXR）和Takeda G蛋白偶联受体5（TGR5）双重激动剂，EC 50 值分别为30nM和630nM。

  • GC33762 structure
    GC33762Deoxycholic acid (Cholanoic Acid)
    CAS: 83-44-3
    纯度: >98.00%

    Deoxycholic acid (Cholanoic Acid)是一种胆汁酸，肠道代谢副产物，可以激活G 蛋白偶联胆汁酸受体TGR5。

  • GC33768 structure
    GC33768Deoxycholic acid sodium salt (Sodium deoxycholate)
    CAS: 302-95-4
    纯度: >99.00%

    Deoxycholic acid sodium salt (Sodium deoxycholate)是一种胆汁酸，是肠道代谢的副产物，可激活 G 蛋白偶联胆汁酸受体 TGR5。

  • GC34775 structure
    GC34775SBI-115
    CAS: 882366-16-7
    纯度: >99.50% / >98.00%

    SBI-115是一种G蛋白胆汁酸偶联受体1（TGR5；GPCR19）拮抗剂。

  • GC36319 structure
    GC36319INT-777 R-enantiomer
    CAS: 1198786-98-9

    INT-777 R-enantiomer 是 INT-77 的 R 型异构体，对 TGR5 的 EC50 值为 4.79 μM，活性比 INT-777 低。

  • GC40637 structure
    GC40637BAR501
    CAS: 1632118-69-4
    纯度: >98.00%

    A selective GP-BAR1 agonist

  • GC46012 structure
    GC46012DY 268
    CAS: 1609564-75-1
    纯度: >98.00%

    An FXR antagonist

  • GN10489 structure
    GN10489Hyodeoxycholic acid
    CAS: 83-49-8
    纯度: >99.00%

    A secondary bile acid

  • GC13681 structure
    GC13681INT-777
    CAS: 1199796-29-6
    纯度: >98.00%

    INT-777 是一种新型特异性半合成 TGR5 激动剂，用于减轻 AD 小鼠模型的心肌细胞损伤，改善认知障碍和突触功能障碍。