Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
[1] L Paw?owski, et al. Pol J Pharmacol Pharm. Mar-Apr 1985;37(2):179-96.
















