mAChR
mAChR(毒蕈碱型乙酰胆碱受体)
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR 相关产品(183)
- GC10508Solifenacin hydrochlorideCAS: 180468-39-7纯度: >99.00%
Solifenacin hydrochloride (YM905 hydrochloride) 是一种毒蕈碱受体拮抗剂，对 M1、M2 和 M3 受体的 pKis 分别为 7.6、6.9 和 8.0。
- GC10822Clozapine N-oxide (CNO)CAS: 34233-69-7纯度: >98.00%
Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。
- GC10863Otilonium BromideCAS: 26095-59-0纯度: >99.00%
An L- and T-type calcium channel inhibitor and mAChR antagonist
- GC10972Gallamine TriethiodideCAS: 65-29-2纯度: >98.00%
An allosteric modulator of muscarinic acetylcholine receptors
- GC11219(R)-(+)-TolterodineCAS: 124937-51-5纯度: >99.50%
(R)-(+)-Tolterodine(PNU-200583) 是一种有效的毒蕈碱受体拮抗剂，在体内对膀胱的选择性优于唾液腺。
- GC11831Umeclidinium bromideCAS: 869113-09-7纯度: >98.00%
A muscarinic acetylcholine receptor antagonist
- GC13361Flavoxate hydrochlorideCAS: 3717-88-2纯度: >99.50%
An internal standard for the quantification of flavoxate
- GC13403Pirenzepine dihydrochlorideCAS: 29868-97-1纯度: >99.00% / >98.00%
A muscarinic M 1 receptor antagonist
- GC13618TarafenacinCAS: 385367-47-5
Tarafenacin(SVT-40776) 是一种高度选择性的 M3 毒蕈碱受体拮抗剂 (Ki= 0.19 nM)，选择性比 M2 受体高约 200 倍。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10219 | AF-DX 116 | 102394-31-0 | >99.50% | |
A muscarinic M 2 receptor antagonist | ||||
| GC10264 | Arecoline hydrobromide | 300-08-3 | >99.50% | |
Muscarinic acetylcholine receptor agonist | ||||
| GC10300 | Diphenidol HCl | 3254-89-5 | >99.00% | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC10508 | Solifenacin hydrochloride | 180468-39-7 | >99.00% | |
Solifenacin hydrochloride (YM905 hydrochloride) 是一种毒蕈碱受体拮抗剂，对 M1、M2 和 M3 受体的 pKis 分别为 7.6、6.9 和 8.0。 | ||||
| GC10621 | Biperiden HCl | 1235-82-1 | - | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC10822 | Clozapine N-oxide (CNO) | 34233-69-7 | >98.00% | |
Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。 | ||||
| GC10863 | Otilonium Bromide | 26095-59-0 | >99.00% | |
An L- and T-type calcium channel inhibitor and mAChR antagonist | ||||
| GC10972 | Gallamine Triethiodide | 65-29-2 | >98.00% | |
An allosteric modulator of muscarinic acetylcholine receptors | ||||
| GC11035 | Hyoscyamine | 101-31-5 | >98.00% | |
A muscarinic receptor antagonist | ||||
| GC11219 | (R)-(+)-Tolterodine | 124937-51-5 | >99.50% | |
(R)-(+)-Tolterodine(PNU-200583) 是一种有效的毒蕈碱受体拮抗剂，在体内对膀胱的选择性优于唾液腺。 | ||||
| GC11385 | G-Protein antagonist peptide | 143675-79-0 | - | |
G-蛋白拮抗肽是抑制G蛋白与其受体结合的P物质相关肽。 | ||||
| GC11831 | Umeclidinium bromide | 869113-09-7 | >98.00% | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC12311 | Trihexyphenidyl hydrochloride | 52-49-3 | >99.50% | |
A muscarinic M 1 receptor antagonist | ||||
| GC12411 | RHC 80267 | 83654-05-1 | >99.50% | |
RHC 80267是一种有效的、选择性二酰基甘油脂酶（DAGL）抑制剂，RHC 80267还能够抑制胆碱酯酶活性（IC₅₀=4μM），可抑制环氧化酶（COX）活性和磷脂酰胆碱的水解。 | ||||
| GC12554 | Tiotropium Bromide | 136310-93-5 | >99.50% | |
A muscarinic receptor antagonist | ||||
| GC12717 | Ipratropium Bromide | 22254-24-6 | >98.50% | |
A muscarinic receptor antagonist | ||||
| GC13134 | Tiotropium Bromide hydrate | 139404-48-1 | - | |
A muscarinic receptor antagonist | ||||
| GC13191 | Irsogladine | 57381-26-7 | >99.50% | |
A gastroprotective agent | ||||
| GC13361 | Flavoxate hydrochloride | 3717-88-2 | >99.50% | |
An internal standard for the quantification of flavoxate | ||||
| GC13403 | Pirenzepine dihydrochloride | 29868-97-1 | >99.00% / >98.00% | |
A muscarinic M 1 receptor antagonist | ||||
| GC13445 | LY2119620 | 886047-22-9 | >99.50% | |
LY2119620是一种muscarinic M 2 /M 4 受体选择性正性变构调节剂。 | ||||
| GC13618 | Tarafenacin | 385367-47-5 | - | |
Tarafenacin(SVT-40776) 是一种高度选择性的 M3 毒蕈碱受体拮抗剂 (Ki= 0.19 nM)，选择性比 M2 受体高约 200 倍。 | ||||
| GC13897 | Homatropine Bromide | 51-56-9 | >99.50% | |
An anticholinergic agent | ||||
| GC14096 | Aclidinium Bromide | 320345-99-1 | >98.00% | |
A muscarinic acetylcholine receptor antagonist | ||||