GlpBio

GPR84

GPR84(G蛋白偶联受体84)

GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14+ monocytes and THP-1 cells.

GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.

GPR84 相关产品(8)

  • GC11350 structure
    GC113506-OAU
    CAS: 83797-69-7
    纯度: >99.50%

    6-OAU是G蛋白偶联受体84（GPR84）的特异性激动剂，可以诱导PMNs（polymorphonuclear leukocytes）和巨噬细胞的趋化以及巨噬细胞的促炎反应。

  • GC31698 structure
    GC31698PBI-4050 sodium salt (Setogepram (sodium salt))
    CAS: 1254472-97-3
    纯度: >99.50%

    Fezagepras (Setogepram) sodium 作为 GPR40 的口服活性激动剂和 GPR84 的拮抗剂或反向激动剂。

  • GC31712 structure
    GC31712GPR84 antagonist 8
    CAS: 1445846-30-9
    纯度: >99.50%

    GPR84antagonist8是一种选择性GPR84拮抗剂。

  • GC64229 structure
    GC64229GPR84 antagonist 1
    CAS: 2762180-28-7

    GPR84 antagonist 1 是一种高亲和力、高选择性的人 GPR84 竞争性拮抗剂。

  • GC69187 structure
    GC69187GPR84 antagonist 2
    CAS: 2244269-74-5
    纯度: >99.00%

    GPR84 antagonist 2 (compound 33) 是一种口服有效的，选择性的 GPR84 拮抗剂(IC50=8.95 nM)。GPR84 antagonist 2 在钙动员试验中显示出更强的效力，并在 GPR84 激活时抑制中性粒细胞和巨噬细胞的趋化性。GPR84 antagonist 2 具有研究溃疡性结肠炎的潜力。

  • GC71478 structure
    GC71478OX04528
    纯度: >99.00%

    OX04528（化合物68）是一种强效的、G蛋白偏向的、口服活性的GPR84激动剂。

  • GC71501 structure
    GC71501TUG-2208
    纯度: >98.00%

    TUG-2208(化合物42a)是一种GPR84激动剂(pEC50=8.98)，具有低亲脂性、良好的溶解度、体外渗透性和微粒体稳定性。

  • GC73332 structure
    GC73332GPR84 antagonist 3
    CAS: 2815263-05-7
    纯度: >99.00%

    GPR84 antagonist 3（化合物42）是一种有效的GPR84 （g蛋白偶联受体84）拮抗剂。