GlpBio

Bradykinin Receptors

Bradykinin Receptors(缓激肽受体)

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

Bradykinin Receptors 相关产品(29)

  • GA20221 structure
    GA20221(Hyp³)-Bradykinin
    CAS: 37642-65-2

    (Hyp³)-缓激肽，天然存在的肽激素，是一种缓激肽受体激动剂。

  • GC10255 structure
    GC10255Lys-[Des-Arg9]Bradykinin
    CAS: 71800-36-7

    bradykinin B1 receptor agonist

  • GC11961 structure
    GC11961Sar-[D-Phe8]-des-Arg9-Bradykinin
    CAS: 126959-88-4
    纯度: >99.00%

    selective bradykinin B1 receptor agonist

  • GC13179 structure
    GC13179R 892
    CAS: 229030-05-1

    bradykinin B1 receptor antagonist

  • GC14629 structure
    GC14629Bombinakinin-GAP
    CAS: 573671-91-7

    Bioactive bradykinin-related peptide

  • GC15188 structure
    GC15188MEN 11270
    CAS: 235082-52-7

    B2 bradykinin receptor antagonist

  • GC15587 structure
    GC15587HOE 140
    CAS: 130308-48-4
    纯度: >98.50%

    HOE 140 (HOE-140) 是一种有效且特异性的缓激肽 B2 受体肽拮抗剂，IC50 和 Ki 分别为 1.07 nM 和 0.798 nM。

  • GC16110 structure
    GC16110R 715
    CAS: 185052-09-9

    缓激肽 B1 受体拮抗剂

  • GC16761 structure
    GC16761Bombinakinin M
    CAS: 509151-65-9

    Potent bradykinin receptor agonist

  • GC16820 structure
    GC16820ELN441958
    CAS: 913064-47-8
    纯度: >98.00%

    ELN441958是一种强效、竞争性且选择性的bradykinin B1受体拮抗剂，K i 值为0.26nM。

  • GC17164 structure
    GC17164Lys-Bradykinin
    CAS: 342-10-9

    Endogenous bradykinin receptor agonist

  • GC17933 structure
    GC17933WIN 64338 hydrochloride
    CAS: 163727-74-0

    WIN 64338 hydrochloride 是一种有效的、选择性的、非肽竞争性缓激肽 B2 受体拮抗剂。

  • GC18038 structure
    GC18038[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
    CAS: 118122-39-7

    Selective bradykinin B2 receptor agonist

  • GC19339 structure
    GC19339SSR240612
    CAS: 464930-42-5
    纯度: >95.00%

    SSR240612是一种新的、有效的、具有口服活性的特异性非肽慢激肽B1受体拮抗剂，可抑制Lys0-desAr9-BK (10nM) 诱导的人成纤维细胞MRC5中肌醇单磷酸的形成，IC 50 为1.9nM。

  • GC31926 structure
    GC31926FR167344 free base
    CAS: 215258-13-2

    FR167344freebase是有口服活性，非多肽的缓激肽受体B2(bradykininreceptorB2)拮抗剂，对B2有高亲和力，IC50值为65nM，对B1受体没有结合力。

  • GC32576 structure
    GC32576Bradykinin 1-3
    CAS: 23815-91-0

    Bradykinin(1-3)是一个含3个氨基酸的残基肽。Bradykinin(1-3)是由脯氨酰内肽酶切割形成的一种氨基截短的激肽肽。

  • GC32592 structure
    GC32592Bradykinin 1-5
    CAS: 23815-89-6
    纯度: >99.00%

    Bradykinin(1-5)是Bradykinin的主要稳定代谢物，由血管紧张素转换酶(ACE)经蛋白水解作用形成。

  • GC32601 structure
    GC32601Bradykinin 1-7 (Bradykinin Fragment 1-​7)
    CAS: 23815-87-4

    缓激肽 1-7（缓激肽片段 1-7）是一种氨基截短的缓激肽。

  • GC32605 structure
    GC32605Bradykinin 1-6
    CAS: 23815-88-5
    纯度: >98.50%

    Bradykinin(1-6)是一种氨基截短的激肽肽。Bradykinin(1-6)是由羧肽酶Y切割形成的一种稳定的Bradykinin代谢物。

  • GC33850 structure
    GC33850[Des-Arg9]-Bradykinin acetate
    CAS: 23827-91-0

    An active metabolite of bradykinin and agonist of bradykinin B 1 receptors

  • GC34042 structure
    GC34042Bradykinin 2-9 (Des-Arg1-bradykinin)
    CAS: 16875-11-9
    纯度: >99.50%

    缓激肽 2-9 (Des-Arg1-bradykinin) 是一种氨基截短的缓激肽。

  • GC35015 structure
    GC35015[Des-Arg9]-Bradykinin
    CAS: 15958-92-6
    纯度: >98.00%

    An active metabolite of bradykinin and agonist of bradykinin B 1 receptors

  • GC35548 structure
    GC35548Bradykinin
    CAS: 58-82-2
    纯度: >98.00%

    Bradykinin是一种强效血管舒张肽，通过刺激特异性内皮B2受体发挥血管舒张作用，诱导前列环素、一氧化氮和内皮衍生超极化因子的释放。

  • GC43888 structure
    GC43888Icatibant (acetate)
    CAS: 138614-30-9
    纯度: >99.50%

    A synthetic peptide antagonist of the bradykinin B 2 receptor