(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin and a peptide agonist of the bradykinin B1 receptor.1,2 It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 ?M, respectively).3 (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.2 It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).4 (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.5
1.Bastian, S., Loillier, B., Paquet, J.L., et al.Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterizationBr. J. Pharmacol.122(2)393-399(1997) 2.Leeb-Lundberg, L.M.F., Marceau, F., Müller-Esterl, W., et al.International union of pharmacology. XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequencesPharmacol. Rev.57(1)27-77(2005) 3.Hess, J.F., Borkowski, J.A., Macneil, T., et al.Differential pharmacology of cloned human and mouse B2 bradykinin receptorsMol. Pharmacol.45(1)1-8(1994) 4.Rhaleb, N.E., Drapeau, G., Dion, S., et al.Structure-activity studies on bradykinin and related peptides: AgonistsBr. J. Pharmacol.99(3)445-448(1990) 5.Drapeau, G., deBlois, D., and Marceau, F.Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kininsJ. Pharmacol. Exp. Ther.259(3)997-1003(1991)