Neurokinin Receptor
Neurokinin Receptor(神经激肽受体)
There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.
Neurokinin Receptor 相关产品(75)
- GC11801Neurokinin B (human, porcine)CAS: 86933-75-7纯度: >98.00%
Neurokinin B (human, porcine) 属于肽的速激肽家族。
- GC13239Hemokinin 1 (mouse)CAS: 208041-90-1纯度: >98.00%
Hemokinin 1 (mouse) 是一种选择性的神经激肽-1 受体激动剂，对人 NK1 受体和人 NK2 受体的 Ki 分别为 0.175 nM 和 560 nM。
- GC15122[bAla8]-Neurokinin A(4-10)CAS: 122063-01-8纯度: >98.00%
[bAla8]-Neurokinin A(4-10) 是一种神经激肽 2 (NK2) 受体激动剂。
- GC25618Maropitant citrateCAS: 359875-09-5
Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties
- GC30104Fezolinetant (ESN-364)CAS: 1629229-37-3纯度: >98.00%
Fezolinetant (ESN-364) 是一种神经激肽 3 受体 (NK3R) 的拮抗剂，用于治疗更年期潮热。
- GC30347NK-1 Antagonist 1CAS: 873947-10-5
NK-1 Antagonist 1 (NK-1 Antagonist 1) 是一种 NK-1 受体拮抗剂，用于研究 NK-1 相关疾病和病症，如咳嗽、膀胱过度活动症、酒精依赖和抑郁症。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GA20847 | Biotinyl-Substance P | 87468-58-4 | - | |
Biotinyl-Substance P 是生物素标记的 Substance P。 | ||||
| GC10107 | SB-222200 | 174635-69-9 | >99.50% | |
An NK 3 receptor antagonist | ||||
| GC10659 | Fosaprepitant dimeglumine salt | 265121-04-8 | >98.00% | |
A prodrug form of aprepitant | ||||
| GC11738 | Neurokinin A (porcine) | 86933-74-6 | - | |
神经激肽 A（猪）（物质 K）是速激肽家族的一种肽神经递质，通过 NK-2 受体起作用。 | ||||
| GC11801 | Neurokinin B (human, porcine) | 86933-75-7 | >98.00% | |
Neurokinin B (human, porcine) 属于肽的速激肽家族。 | ||||
| GC13239 | Hemokinin 1 (mouse) | 208041-90-1 | >98.00% | |
Hemokinin 1 (mouse) 是一种选择性的神经激肽-1 受体激动剂，对人 NK1 受体和人 NK2 受体的 Ki 分别为 0.175 nM 和 560 nM。 | ||||
| GC13610 | [Sar9,Met(O2)11]-Substance P | 110880-55-2 | - | |
A peptide NK 1 receptor agonist | ||||
| GC14839 | Senktide | 106128-89-6 | >99.00% | |
A potent NK3 receptor agonist | ||||
| GC15122 | [bAla8]-Neurokinin A(4-10) | 122063-01-8 | >98.00% | |
[bAla8]-Neurokinin A(4-10) 是一种神经激肽 2 (NK2) 受体激动剂。 | ||||
| GC15200 | Aprepitant | 170729-80-3 | >99.50% | |
Aprepitant是一种新型的、高选择性的神经激肽-1 （NK-1）受体拮抗剂。 | ||||
| GC15449 | Rolapitant | 552292-08-7 | >98.00% | |
A potent NK 1 receptor antagonist | ||||
| GC15591 | Eprazinone 2HCl | 10402-53-6 | >98.00% | |
An antitussive agent | ||||
| GC15649 | Substance P | 33507-63-0 | >99.00% | |
Substance P作为一种重要的神经肽类神经递质，能够刺激磷脂酰肌醇代谢，EC 50 值为0.36nM。 | ||||
| GC16026 | Talnetant | 174636-32-9 | >99.00% | |
A nonpeptide NK 3 antagonist | ||||
| GC16246 | Fosaprepitant | 172673-20-0 | - | |
A prodrug form of aprepitant | ||||
| GC16408 | GR 159897 | 158848-32-9 | >98.00% | |
A nonpeptide NK 2 receptor antagonist | ||||
| GC17547 | MEN 10376 | 135306-85-3 | - | |
An NK 2 receptor antagonist | ||||
| GC17596 | Netupitant | 290297-26-6 | >99.50% | |
An NK 1 receptor antagonist | ||||
| GC18080 | GR 73632 | 133156-06-6 | - | |
GR 73632 是一种新型速激肽神经激肽 1 (NK-1) 受体激动剂。 | ||||
| GC18128 | L-732,138 | 148451-96-1 | >99.00% | |
An NK 1 receptor antagonist | ||||
| GC25618 | Maropitant citrate | 359875-09-5 | - | |
Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties | ||||
| GC30104 | Fezolinetant (ESN-364) | 1629229-37-3 | >98.00% | |
Fezolinetant (ESN-364) 是一种神经激肽 3 受体 (NK3R) 的拮抗剂，用于治疗更年期潮热。 | ||||
| GC30347 | NK-1 Antagonist 1 | 873947-10-5 | - | |
NK-1 Antagonist 1 (NK-1 Antagonist 1) 是一种 NK-1 受体拮抗剂，用于研究 NK-1 相关疾病和病症，如咳嗽、膀胱过度活动症、酒精依赖和抑郁症。 | ||||
| GC30861 | Pavinetant (MLE-4901) | 941690-55-7 | >99.50% | |
An NK 3 receptor antagonist | ||||