GlpBio

[Sar9,Met(O2)11]-Substance P

目录号: GC13610纯度: >98%同义词: 精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺
COASDSData Sheet
A peptide NK1 receptor agonist
[Sar9,Met(O2)11]-Substance P
Cas No.: 110880-55-2
规格价格库存数量操作
1mg¥720.00现货
1
5mg¥2,880.00现货
1
10mg¥4,320.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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产品描述 Description

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].
Reference:
[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.

实验参考方法 Experimental Reference Method

Kinase experiment:

Rats initially receive an i.c.v. injection of artificial cerebrospinal fluid (aCSF; 1 μl) followed 60 min later by a single dose of either [Sar9,Met(O2)11]-Substance P (10 pmol (n=9), 25 pmol (n=9), 65 pmol (n=8) or 100 pmol (n=8)) or septide (10 pmol (n=12), 25 pmol (n=9), 65 pmol (n=6) or 100 pmol (n=6)) to construct a complete dose-response curve. Each rat is selected randomly and injected with only one of the two agonists for the remainder of the protocol. Increasing doses of [Sar9,Met(O2)11]-Substance P or septide are given at 24 h intervals on day 1 (10 pmol), day 2 (25 pmol), day 3 (65 pmol) and day 4 (100 pmol). Control rats (n=18) receive only the vehicle (aCSF) each day of experiment. Peptides are administered in a volume of 1 μL of vehicle followed by 5 μL flush volume of aCSF which corresponds to the void volume of the catheter. Each dose is calculated per rat in 1 μL solution[1].

References:

[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
110880-55-2
同义词
精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺
SMILES
CC(C[C@@](/N=C(O)/CN(C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@]2([H])CCCN2C([C@](N)([H])CCCNC(N)=N)=O)([H])CCCCN)=O)([H])CCC(O)=N)([H])CCC(O)=N)([H])CC3=CC=CC=C3)([H])CC4=CC=CC=C4)=O)C)([H])/C(O)=N/[C@@](C(O)=
分子式
C64H100N18O15S
分子量
1393 g/mol
溶解性
Soluble to 1 mg/ml in sterile water
保存条件
Desiccate at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol