Sophoricoside is a polyketide synthase-derived isoflavone glycoside that has been found in S. japonica and has diverse biological activities.1,2,3,4,5 It inhibits lipid accumulation induced by oleic acid in HepG2 cells and stimulates glucose uptake in C2C12 mouse skeletal muscle myoblasts when used at a concentration of 10 ?M.2 Sophoricoside (2 mg/kg) reduces scratching behavior induced by compound 48/80 or histamine in mice, as well as reduces serum levels of IgE in a mouse model of atopic dermatitis.3 It increases serum levels of osteocalcin and alkaline phosphatase (ALP) and restores mechanical bone hardness in an ovariectomized rat model of osteoporosis.4 Sophoricoside (80 and 160 mg/kg) decreases hepatic cholesterol and triglyceride levels, serum LDL and apolipoprotein B levels, and hepatic injury in a mouse model of fructose-induced liver injury.5
1.Trantas, E.A., Koffas, M.A.G., Xu, P., et al.When plants produce not enough or at all: Metabolic engineering of flavonoids in microbial hostsFront. Plant Sci.6(7)(2015) 2.Wu, C., Luan, H., Wang, S., et al.Modulation of lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes by sophoricosideMolecules18(12)15624-15635(2013) 3.Kim, S.-J., Lee, G.-Y., Jung, J.-W., et al.The ameliorative effect of sophoricoside on mast cell-mediated allergic inflammation in vivo and in vitroMolecules18(5)6113-6127(2013) 4.Abdallah, H.M., Al-Abd, A.M., Asaad, G.F., et al.Isolation of antiosteoporotic compounds from seeds of Sophora japonicaPLoS One9(6)e98559(2014) 5.Li, W., and Lu, Y.Hepatoprotective effects of sophoricoside against fructose-induced liver injury via regulating lipid metabolism, oxidation, and inflammation in miceJ. Food Sci.83(2)552-558(2018)