Lasalocid is a polyketide-synthase derived ionophore antibiotic originally isolated from S. lasaliensis.1,2 It binds to monovalent and divalent cations, including potassium, sodium, calcium, and magnesium cations.3 Lasalocid (0.01 and 0.1 ?g/ml) is active against E. tenella.4 In vivo, lasalocid (125 ppm in the feed) reduces the severity of gastrointestinal lesions in chicks experimentally infected with E. tenella, E. maxima, E. necatrix, E. brunetti, or E. acervulina. It has been found in groundwater.5 Formulations containing lasalocid have been used in the treatment of coccidiosis in poultry.
1.Migita, A., Watanabe, M., Hirose, Y., et al.Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensisBiosci. Biotechnol. Biochem.73(1)169-176(2009) 2.Mitrovic, M., and Schildknecht, E.G.Anticoccidial activity of lasalocid (X-537A) in chicksPoult. Sci.53(4)1448-1455(1974) 3.Antonenko, Y.N., and Yaguzhinsky, L.S.The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid ABiochim. Biophys. Acta938(2)125-130(1988) 4.Folz, S.D., Lee, B.L., Nowakowski, L.H., et al.Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycinVet. Parasitol.28(1-2)1-9(1988) 5.Mooney, D., Richards, K.G., Danaher, M., et al.An investigation of anticoccidial veterinary drugs as emerging organic contaminants in groundwaterSci. Total Environ.746141116(2020)