LC3-mHTT-IN-AN1 is a linker molecule that interacts with the autophagosome protein microtubule-associated protein 1 light chain 3β (LC3B) and mutant huntingtin (Hdh).1 It decreases HdhQ7/Q140, but not wild-type huntingtin, levels in primary mouse cortical neurons when used at a concentration of 300 nM. LC3-mHTT-IN-AN1 increases survival of Drosophila expressing human HdhQ128.
1.Li, Z., Wang, C., Wang, Z., et al.Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compoundsNature575(7781)203-209(2019)