Hexadecanedioic acid is a dicarboxylic fatty acid that has been found in the suberin component of silver birch (B. pendula) outer bark and soil.1,2 It stimulates mitochondrial respiration and decreases the production of reactive oxygen species (ROS) induced by rotenone in isolated rat liver mitochondria when used at concentrations of 100 and 40 ?M, respectively.3
1.Karnaouri, A., Lange, H., Crestini, C., et al.Chemoenzymatic fractionation and characterization of pretreated birch outer barkACS Sustainable Chem. Eng.4(10)5289-5302(2016) 2.Hamer, U., Rumpel, C., and Dignac, M.-F.Cutin and suberin biomarkers as tracers for the turnover of shoot and root derived organic matter along a chronosequence of Ecuadorian pasture soilsEur. J. Soil Sci.63(6)808-819(2012) 3.Sememova, A.A., V.N., S., Pavlova, S.I., et al.ω-Hydroxypalmitic and α,ω-hexadecanedioic acids as activators of free respiration and inhibitors of H2O2 generation in liver mitochondriaBiochem. Moscow Suppl. Ser. A14(1)24-33(2020)