GlpBio

Oxytocin Receptors

Oxytocin Receptors(催产素受体)

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Oxytocin Receptors 相关产品(22)

  • GC11042 structure
    GC11042WAY 267464 dihydrochloride
    CAS: 847375-16-0

    WAY 267464 dihydrochloride 是一种非肽催产素受体 (OTR) 激动剂。

  • GC11419 structure
    GC11419Carbetocin
    CAS: 37025-55-1
    纯度: >98.00%

    A peptide oxytocin receptor agonist

  • GC11991 structure
    GC11991L-371,257
    CAS: 162042-44-6
    纯度: >99.00%

    L-371,257 是一种口服生物可利用的、非血脑屏障渗透剂、选择性和竞争性催产素受体 (pA2=8.4) 拮抗剂，对催产素受体 (Ki=19 nM) 和加压素 V1a 受体 (Ki=3.7) 具有高亲和力nM)。

  • GC12194 structure
    GC12194Atosiban
    CAS: 90779-69-4
    纯度: >99.00%

    Atosiban是一种催产素和加压素受体的混合拮抗剂，通过竞争性阻断子宫平滑肌上的催产素受体，有效抑制宫缩，延长妊娠时间。

  • GC14001 structure
    GC14001TC OT 39
    CAS: 479232-57-0

    oxytocin receptor partial agonist

  • GC16222 structure
    GC16222Oxytocin
    CAS: 50-56-6
    纯度: >98.00% / >97.00%

    Oxytocin是一种多效的下丘脑肽，有助于分娩、哺乳和亲社会行为。

  • GC16620 structure
    GC16620L-368,899 hydrochloride
    CAS: 160312-62-9
    纯度: >98.00%

    A non-peptide oxytocin receptor antagonist

  • GC17249 structure
    GC17249PF-3274167
    CAS: 900510-03-4

    An oxytocin receptor antagonist

  • GC30594 structure
    GC30594Epelsiban (GSK 557296)
    CAS: 872599-83-2

    Epelsiban (GSK 557296) (GSK 557296) 是一种有效的、选择性的和口服生物可利用的催产素受体拮抗剂，对人催产素受体的 pKi 为 9.9。

  • GC31068 structure
    GC31068Retosiban (GSK 221149)
    CAS: 820957-38-8
    纯度: >98.50%

    Retosiban (GSK 221149) (GSK221149A) 是一种有效的选择性催产素拮抗剂，Ki 为 0.65 nM。

  • GC32425 structure
    GC32425OT antagonist 1
    CAS: 479080-38-1

    OTantagonist1(Compound4)是一种有效的选择性催产素(Oxytocin)拮抗剂，Ki为50nM。

  • GC32431 structure
    GC32431OT antagonist 3
    CAS: 925703-75-9

    OTantagonist3是一种催产素(oxytocin,OT)拮抗剂，详细信息请参考专利文献WO2007017752A1。

  • GC33540 structure
    GC33540OT-R antagonist 2 (Oxytocin receptor antagonist 2)
    CAS: 364071-16-9

    OT-R 拮抗剂 2（催产素受体拮抗剂 2）是一种非肽类低分子量 OT-R 拮抗剂。

  • GC34364 structure
    GC34364OT antagonist 1 demethyl derivative
    CAS: 2763705-17-3

    OTantagonist1demethylderivative是OTantagonist1的去甲基化产物.OTantagonist1(Compound4)是一种有效的选择性催产素(Oxytocin)拮抗剂，Ki为50nM。

  • GC36823 structure
    GC36823OT-R antagonist 1
    CAS: 364071-17-0
    纯度: >98.00%

    OT-R antagonist 1是一种新型有效的选择性非肽类OT-R拮抗剂, 抑制催产素诱发的细胞内Ca2+活动（IC50=8nM）。

  • GC37635 structure
    GC37635SHR1653
    CAS: 2231770-73-1

    SHR1653是强效的、选择性的、能透过大脑的催产素受体 (OTR) 的拮抗剂，对hOTR 的 IC50 值为 15 nM。

  • GC38922 structure
    GC38922LIT-001
    CAS: 2245072-21-1
    纯度: >98.50%

    LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism.

  • GC39849 structure
    GC39849Atosiban acetate
    CAS: 914453-95-5
    纯度: >99.50%

    An oxytocin receptor antagonist

  • GC44526 structure
    GC44526Oxytocin (acetate)
    CAS: 6233-83-6
    纯度: >99.00% / >95.00%

    A peptide hormone best known for its role in reproductive biology

  • GC63036 structure
    GC63036L-372662
    CAS: 162045-26-3
    纯度: >98.50%

    L-372662 是一种有效的具有口服活性的非肽催产素拮抗剂，其 Ki 值为 4.8。野生型 hOTR 和[A318G]OTR 的 L-372662 的 Kd 值分别为 5.8 nM 和 73 nM。L-372,662 对 OTR:V1a 具有选择性。

  • GC68698 structure
    GC68698[Asp5]-Oxytocin
    CAS: 65907-78-0
    纯度: >99.00%

    [Asp5]-Oxytocin 是一种高效力的 5 位 (5-position)-神经垂体激素类似物。[Asp5]-Oxytocin 可引起体外大鼠子宫收缩，并能够被镁离子增强。[Asp5]-Oxytocin 具有大鼠子宫收缩素、禽血管抑制剂和大鼠抗利尿剂的能力。

  • GC74398 structure
    GC74398Vasopressin Dimer (parallel) (TFA)
    纯度: >99.00%

    Vasopressin Dimer (parallel) (TFA)是加压素的平行二聚体。