Oxytocin is a pleiotropic hypothalamic peptide that helps in childbirth, lactation and prosocial behavior[1]. Oxytocin can act as a stress response molecule with anti-inflammatory, antioxidant and neuroprotective effects[2]. Oxytocin can regulate the growth of cancer cells by activating oxytocin receptors[3].
In vitro, Oxytocin (1μM) treatment of SH-SY5Y cells for 12h significantly increased the amount of total protein in cell lysates and significantly reduced the concentration of neurotrophic growth factor (NGF)[4]. Treatment of human umbilical vein endothelial cells (HUVEC) with Oxytocin (1nM) stimulated cell migration and invasion[5]. Treatment of hTERTmyo and SK-UT-1 cells with Oxytocin (1μM) for 24-96h inhibited the proliferation of both cells in a time-dependent manner[6].
In vivo, Oxytocin (0.2mg/kg) was administered intranasally to treat valproic acid (VPA)-induced autistic mice, which improved the behavior of autistic mice, reduced anxiety, depression, and repetitive behaviors, and improved social interactions[7]. Oxytocin (0.1-0.3mg/kg) was administered subcutaneously to treat phencyclidine-induced hyperactive rats, which significantly reduced the hyperactive behavior of the rats and increased prosocial behavior[8].
References:
[1] Tarsha M S, Narvaez D. The evolved nest, oxytocin functioning, and prosocial development[J]. Frontiers in Psychology, 2023, 14: 1113944.
[2] Kamrani-Sharif R, Hayes A W, Gholami M, et al. Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: a mechanistic graphical review[J]. Neuropeptides, 2023, 101: 102352.
[3] Cassoni P, Sapino A, Marrocco T, et al. Oxytocin and oxytocin receptors in cancer cells and proliferation[J]. Journal of neuroendocrinology, 2004, 16(4): 362-364.
[4] Bakos J, Strbak V, Ratulovska N, et al. Effect of oxytocin on neuroblastoma cell viability and growth[J]. Cellular and molecular neurobiology, 2012, 32: 891-896.
[5] Cattaneo M G, Chini B, Vicentini L M. Oxytocin stimulates migration and invasion in human endothelial cells[J]. British journal of pharmacology, 2008, 153(4): 728-736.
[6] Busnelli M, Rimoldi V, Viganò P, et al. Oxytocin-induced cell growth proliferation in human myometrial cells and leiomyomas[J]. Fertility and sterility, 2010, 94(5): 1869-1874.
[7] Wang Y, Zhao S, Liu X, et al. Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice[J]. Biomedicine & Pharmacotherapy, 2018, 107: 262-269.
[8] Kohli S, King M V, Williams S, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats[J]. Neuropsychopharmacology, 2019, 44(2): 295-305.
Oxytocin是一种多效的下丘脑肽，有助于分娩、哺乳和亲社会行为[1]。Oxytocin能够作为一种压力应对分子，具有抗炎、抗氧化和神经保护作用[2]。Oxytocin能够通过激活催产素受体对癌细胞起生长调节作用[3]。
在体外，Oxytocin（1μM）处理SH-SY5Y细胞12h，显著增加了细胞裂解物中的总蛋白量，显著降低了神经营养生长因子（NGF）的浓度[4]。Oxytocin（1nM）处理人脐静脉内皮细胞（HUVEC），刺激了细胞迁移和侵袭[5]。Oxytocin（1μM）处理hTERTmyo和SK-UT-1细胞24-96h，以时间依赖性方式抑制了两种细胞的增殖[6]。
在体内，Oxytocin（0.2mg/kg）通过鼻腔给药治疗丙戊酸（VPA）诱导的自闭症小鼠，改善了自闭症小鼠的行为，减少了焦虑、抑郁和重复行为，并改善了社交互动[7]。Oxytocin（0.1-0.3mg/kg）通过皮下注射治疗苯环利定诱导的多动症大鼠，显著减少了大鼠多动行为，增加了亲社会行为[8]。