GlpBio

EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

EBI2/GPR183 相关产品(5)

  • GC14433 structure
    GC144337α,25-dihydroxy Cholesterol
    CAS: 64907-22-8
    纯度: ≥95.00% / >99.50%

    A potent and selective agonist of GPR183

  • GC15430 structure
    GC15430NIBR189
    CAS: 1599432-08-2
    纯度: >98.00%

    A selective antagonist of EBI2 (GPR183)

  • GC31651 structure
    GC31651GSK682753A
    CAS: 1334294-76-6
    纯度: >99.50%

    GSK682753A是EB病毒诱导受体2(EBI2)的反向激动剂,IC50值为53.6nM。

  • GC38820 structure
    GC38820ML401
    CAS: 1597489-14-9
    纯度: >99.50%

    ML401, a potent chemical probe, selectively antagonizes G-protein coupled receptor 183 (GPR183, EBI2) with an IC50 of 1.03 nM, and displays activity in a chemotaxis assay with IC50 of 6.24 nM.

  • GC65986 structure
    GC65986SAE-14
    CAS: 1241280-25-0
    纯度: >98.00%

    SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂，IC50值为 28.5 nM，可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导， IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。