GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC30732 structure
    GC30732Guanosine (DL-Guanosine)
    CAS: 118-00-3
    纯度: >98.00%

    A purine nucleoside

  • GC30735 structure
    GC30735(S)-Leucic acid
    CAS: 13748-90-8
    纯度: >98.00%

    Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.

  • GC30742 structure
    GC307421,3-Diaminopropane
    CAS: 109-76-2
    纯度: >98.00%

    1,3-Diaminopropane是一种三碳二胺，是鸟氨酸脱羧酶抑制剂。

  • GC30744 structure
    GC30744Norepinephrine (Adrenor)
    CAS: 51-41-2
    纯度: >98.00%

    (-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

  • GC30745 structure
    GC30745L-Palmitoylcarnitine
    CAS: 2364-67-2
    纯度: >98.00% / >97.00%

    L-Palmitoylcarnitine 是一种重要的内源性脂肪酸代谢物，可同时提高离子通道对 ATP 的敏感性，IC 50 值在 30.3 ± 5.5μM和62.0 ± 2.7之间。

  • GC30749 structure
    GC307491,3-Dimethyluric acid
    CAS: 944-73-0
    纯度: >98.00%

    1,3-二甲基尿酸（1,3-Dimethyluric acid）是一种氧嘌呤，它是 7,9-二氢-1H-嘌呤-2,6,8(3H)-三酮，在 N-1 和 N-3 被甲基取代。是人体茶碱代谢的产物。1,3-二甲基尿酸是尿路结石中的嘌呤成分之一。

  • GC30753 structure
    GC30753Ureidopropionic acid
    CAS: 462-88-4
    纯度: >98.00%

    Ureidopropionic acid is an intermediate in the metabolism of uracil.

  • GC30757 structure
    GC30757DL-Homocysteine thiolactone hydrochloride
    CAS: 6038-19-3

    A derivative of DL-homocysteine

  • GC30758 structure
    GC30758m-Coumaric acid
    CAS: 588-30-7

    m-Coumaricacid是来自咖啡酸的多酚代谢物，由肠道微生物群形成，体液中的量是饮食依赖性的。

  • GC30760 structure
    GC30760Pentadecanoic acid
    CAS: 1002-84-2
    纯度: >98.00%

    A saturated fatty acid

  • GC30765 structure
    GC30765Docosahexaenoic Acid (DHA)
    CAS: 6217-54-5
    纯度: >98.00% / >99.50% / >95.00%

    二十二碳六烯酸 (DHA) 是一种长链多不饱和脂肪酸，对婴儿和成人均有活性。

  • GC30767 structure
    GC30767Heparan Sulfate
    CAS: 9050-30-0
    纯度: {{1-9}Po-58.0 IU/mg}

    硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。

  • GC30775 structure
    GC30775Histamine (Ergamine)
    CAS: 51-45-6
    纯度: >99.00% / >98.00%

    A biogenic amine

  • GC30783 structure
    GC30783AZD5904
    CAS: 618913-30-7
    纯度: >99.50%

    A myeloperoxidase inhibitor

  • GC30786 structure
    GC30786Sacubitrilat (LBQ-657)
    CAS: 149709-44-4
    纯度: >98.00%

    A neprilysin inhibitor

  • GC30795 structure
    GC30795D-Galactose (D-(+)-Galactose)
    CAS: 59-23-4
    纯度: >99.00%

    A natural aldohexose

  • GC30806 structure
    GC30806Cyclo(his-pro) (Cyclo(histidyl-proline))
    CAS: 53109-32-3
    纯度: >98.00%

    Cyclo(his-pro) (Cyclo(histidyl-proline))是一种内源性、可透过血脑屏障的环状二肽，来源于促甲状腺激素释放激素（TRH）的分解代谢。

  • GC30842 structure
    GC30842Androsterone (5α-Androstan-3α-ol-17-one)
    CAS: 53-41-8
    纯度: >98.00% / >95.00%

    Androsterone (5α-Androstan-3α-ol-17-one)是睾酮的一种代谢产物，可调节癫痫发作的易感性。

  • GC30872 structure
    GC30872Pipecolic acid
    CAS: 535-75-1

    Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.

  • GC30877 structure
    GC30877DPP-IV-IN-2
    CAS: 136259-18-2
    纯度: >98.00%

    DPP-IV-IN-2是二肽基肽酶IV(DPIV)和DP8/9的抑制剂，其IC50值分别为0.1和0.95μM。

  • GC30887 structure
    GC30887NGP555
    CAS: 1304630-27-0
    纯度: >98.00%

    A γ-secretase modulator

  • GC30954 structure
    GC30954Itanapraced (CHF5074)
    CAS: 749269-83-8
    纯度: >98.00%

    A modulator of γ-secretase

  • GC30994 structure
    GC30994Vanilpyruvic acid (Vanylpyruvic acid)
    CAS: 1081-71-6
    纯度: >98.00%

    香草丙酮酸 (Vanylpyruvic acid) 是儿茶酚胺代谢物和香草乳酸的前体。

  • GC31012 structure
    GC31012BMS 433796
    CAS: 935525-13-6

    BMS433796是一种γ-分泌酶抑制剂，用于阿尔茨海默氏病转基因小鼠模型，可降低Aβ活性。