(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2]
Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3]
(-)-去甲肾上腺素（Arterenol、Levarterenol、L-Noradrenaline）是一种天然神经递质和激素。它是肾上腺素能受体的激动剂，对α1、α2和β1肾上腺素能受体的Ki值分别为330、56和740 nM。
(-)-去甲肾上腺素抑制LPS刺激小鼠肺泡巨噬细胞产生TNF-α、IL-6和CXCL2/MIP-2，并促进IL-10的分泌。(-)-去甲肾上腺素能够下调受刺激的肺泡巨噬细胞中NF-κB的活化。[2]
将(-)-去甲肾上腺素注射到老化加速易感8号（SAMP8）小鼠体内可以逆转甲醛积累和(-)-去甲肾上腺素缺乏，并恢复长时程增强和记忆的程度。[3]
[1] Ramos BP, et al. Pharmacol Ther. 2007, 113(3):523-36. [2] Cong Z, et al. Clin Sci (Lond). 2020 Jul 31;134(14):1957-1971. [3] Mei Y,et al. Aging Cell. 2015 Aug;14(4):659-68.