GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC30690 structure
    GC30690m-Tyramine
    CAS: 588-05-6

    m-Tyramine是一种内源性微量胺神经调节剂。m-Tyramine对肾上腺素能(adrenergic)和多巴胺能受体(dopaminergic)有影响。

  • GC30691 structure
    GC30691N-Methylhydantoin
    CAS: 616-04-6

    N-Methylhydantoin (1-Methylhydantoin, Dioxy-creatinine) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam.

  • GC30697 structure
    GC306971-Methylhistamine
    CAS: 501-75-7
    纯度: >98.00%

    1-Methylhistamine是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平。

  • GC30698 structure
    GC30698L-Octanoylcarnitine
    CAS: 25243-95-2

    L-Octanoylcarnitine是辛酰基肉碱的生理活性形式。

  • GC30704 structure
    GC30704Urocanic acid
    CAS: 104-98-3
    纯度: >99.50%

    Urocanic acid is an intermediate in the catabolism of L-histidine.

  • GC30706 structure
    GC30706Maltotriose
    CAS: 1109-28-0

    A trisaccharide

  • GC30707 structure
    GC30707DL-Dopa
    CAS: 63-84-3
    纯度: >98.00%

    DL-Dopa (3,4-Dihydroxy-DL-phenylalanine) is an immediate precursor of dopamine.

  • GC30708 structure
    GC30708Terephthalic acid
    CAS: 100-21-0
    纯度: >99.00%

    Terephthalic acid (para-Phthalic acid, 1,4-Benzenedioic acid), a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry.

  • GC30711 structure
    GC30711D-Threitol
    CAS: 2418-52-2

    D-threitol可以作为阿拉斯加甲虫的防冻剂。

  • GC30712 structure
    GC307125-Methoxytryptophol
    CAS: 712-09-4

    A natural indole

  • GC30713 structure
    GC307132-Oxovaleric acid
    CAS: 1821-02-9
    纯度: >95.00% / >98.00%

    2-Oxovalericacid是在人体血液中发现的一种酮酸。

  • GC30715 structure
    GC30715Guanosine 5'-diphosphate
    CAS: 146-91-8
    纯度: >98.00% / >95.00%

    Guanosine 5'-diphosphate作为一种关键的核苷二磷酸，通过G蛋白信号转导作为细胞内信号级联反应的调节剂。

  • GC30716 structure
    GC30716Levulinic acid (4-Oxovaleric acid)
    CAS: 123-76-2
    纯度: >98.00%

    Levulinic acid (4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid) is used as a precursor for pharmaceuticals, plasticizers, and various other additives.

  • GC30718 structure
    GC307182-Amino-1-phenylethanol
    CAS: 7568-93-6
    纯度: >97.00%

    2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.

  • GC30719 structure
    GC307193-Amino-4-methylpentanoic acid
    CAS: 5699-54-7
    纯度: >98.00%

    3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite.

  • GC30720 structure
    GC307202-Naphthol
    CAS: 135-19-3
    纯度: >99.50%

    2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds.

  • GC30722 structure
    GC30722Anserine
    CAS: 584-85-0

    Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.

  • GC30723 structure
    GC30723Ubiquinone-1
    CAS: 727-81-1
    纯度: >99.00%

    Ubiquinone-1是辅酶Q合成过程中的中间体。

  • GC30724 structure
    GC30724trans-Vaccenic acid
    CAS: 693-72-1
    纯度: >99.00%

    trans-Vaccenic acid是一种单不饱和脂肪酸，是反刍动物来源的脂质中最主要的一种反式异构体。

  • GC30726 structure
    GC30726Eicosadienoic acid
    CAS: 2091-39-6
    纯度: >98.00%

    Eicosadienoic acid能够抑制小鼠5'-单磷酸肌苷脱氢酶（IMPDH）的活性，并且与IMPDH的结合具有竞争性（K i =3.1μM）。

  • GC30727 structure
    GC30727Beta-Cortol
    CAS: 667-65-2
    纯度: >98.00%

    An endogenous metabolite of cortisol

  • GC30728 structure
    GC30728Isobutyryl-L-carnitine
    CAS: 25518-49-4

    An acylcarnitine

  • GC30729 structure
    GC307293-Hydroxyvaleric acid
    CAS: 10237-77-1
    纯度: >98.00%

    3-Hydroxyvalericacid是一种五碳酮体。3-Hydroxyvalericacid可以发生回补反应，即可以补充三羧酸循环的中间产物。

  • GC30730 structure
    GC30730Monoisobutyl phthalic acid
    CAS: 30833-53-5
    纯度: >96.50%

    Monoisobutylphthalicacid是一种邻苯二甲酸酯代谢物，存在于人的精液和肽粪中。