trans-Vaccenic acid is a kind of monounsaturated fatty acid which is the predominant trans isomer found in ruminant fats [1]. trans-Vaccenic acid is the primary precursor for endogenous synthesis of cis-9, trans-11 conjugated linoleic acid in animals and humans [1]. trans-Vaccenic acid exerts anti-inflammatory effects and helps alleviate complications associated with metabolic diseases [2]. trans-Vaccenic acid has been suggested as a beneficial effect in reducing the incidence of heart disease, cancer, and obesity in recent study [3].
trans-Vaccenic acid (0, 50, 100 and 200μM; 72h) inhibited the cell viability of MCF-7 cells in a dose-dependent manner [3]. trans-Vaccenic acid (0, 25, 50 and 100μM; 24h) significantly decreased p-Akt levels and Bad phosphorylation on Ser-136 and Ser-112 of NPC cells [4].
trans-Vaccenic acid (1% in diet; 11~15d; p.o.) increased CD8+ T cell population in tumour-infiltrating lymphocytes (TILs) in C57BL/6 mice implanted with B16F10 tumor [5]. trans-Vaccenic acid (1% in diet; 16 weeks; p.o.) reduced plasma triglyceride (TG), total cholesterol (TC), LDL cholesterol and nonesterified fatty acids (NEFA) concentrations in obese JCR:LA-cp rats [1].
References:
[1] Wang Y, Jacome-Sosa M M, Ruth M R, et al. Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in JCR:LA-cp rats [J]. The Journal of nutrition, 2009, 139(11): 2049-2054.
[2] Cristina M O, Elizabeth B R, Jose R M, et al. Mechanisms and therapeutic potential of key anti-inflammatory metabiotics: trans-vaccenic acid, indole-3-lactic acid, thiamine, and butyric acid [J]. Probiotics and antimicrobial proteins, 2025, 17(5): 2805-2018.
[3] Lim J N, Oh J J, Wang T, et al. trans-11 18:1 vaccenic acid (TVA) has a direct anti-carcinogenic effect on MCF-7 human mammary adenocarcinoma cells [J]. Nutrients, 2014, 6(2): 627-636.
[4] Song J, Wang Y, Fan X, et al. Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway [J]. Lipids in health and disease, 2019, 18(1): 46.
[5] Fan H, Xia S, Xiang J, et al. Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity [J]. Nature, 2023, 623(7989): 1034-1043.
trans-Vaccenic acid是一种单不饱和脂肪酸，是反刍动物来源的脂质中最主要的一种反式异构体[1]。trans-Vaccenic acid是动物和人类内源性合成cis-9, trans-11共轭亚油酸的重要前体物质[1]。trans-Vaccenic acid具有抗炎作用，并有助于缓解与代谢性疾病相关的并发症[2]。近期有研究表明trans-Vaccenic acid具有降低心脏病、癌症和肥胖症发病率的积极作用[3]。
trans-Vaccenic acid（0、50、100和200μM；72h）以浓度依赖的方式抑制MCF-7细胞的细胞活力[3]。trans-Vaccenic acid（0、25、50和100μM；24h）显著降低NPC细胞的p-Akt水平和Ser-136、Ser-112上的Bad的磷酸化水平[4]。
trans-Vaccenic acid（1% in diet；11~15d；p.o.）增加了植入B16F10肿瘤的C57BL/6小鼠的肿瘤浸润淋巴细胞（TILs）中的CD8+ T细胞数量[5]。trans-Vaccenic acid（1% in diet；16 weeks；p.o.）降低了肥胖JCR:LA-cp大鼠血浆中的甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇以及非酯化脂肪酸（NEFA）的浓度[1]。