GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC30636 structure
    GC306363-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI))
    CAS: 874-24-8

    A matrix substance for MALDI-MS

  • GC30638 structure
    GC306383-Hydroxymandelic Acid
    CAS: 17119-15-2

    3-HydroxymandelicAcid是Phenylephrine的代谢物，Phenylephrine是α受体(α-receptor)的激动剂。

  • GC30640 structure
    GC30640Homogentisic acid
    CAS: 451-13-8
    纯度: >97.00%

    An intermediate in aromatic amino acid metabolism

  • GC30641 structure
    GC306411-Naphthol (Fourrine ERN)
    CAS: 90-15-3
    纯度: >98.00%

    1-萘酚（1-Naphthol）用于制造染料、中间体、合成香料，是一种激发态质子转移 (ESPT) 荧光分子探针

  • GC30642 structure
    GC306423-Hydroxydodecanoic acid
    CAS: 1883-13-2
    纯度: >98.00%

    A hydroxy fatty acid

  • GC30645 structure
    GC30645p-Hydroxymandelic acid
    CAS: 1198-84-1
    纯度: >97.00%

    p-Hydroxymandelicacid是一种有价值的芳香类化学品，广泛用于生产药物和食品添加剂。

  • GC30646 structure
    GC30646Skatole(3-Methylindole)
    CAS: 83-34-1
    纯度: >99.50%

    Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

  • GC30649 structure
    GC30649(S)-3,4-Dihydroxybutyric acid
    CAS: 51267-44-8

    (S)-3,4-Dihydroxybutyricacid是一种正常的人体尿液代谢物，在琥珀酸半醛脱氢酶(SSADH)缺乏症患者中浓度增加。

  • GC30651 structure
    GC30651Decyl aldehyde
    CAS: 112-31-2
    纯度: >99.50%

    Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring.

  • GC30652 structure
    GC30652Melanin
    CAS: 8049-97-6
    纯度: >99.00% / >98.00%

    Melanin是一种具有多功能的生物色素，可以抵御环境压力，如紫外线(UV)，氧化剂和电离辐射。

  • GC30654 structure
    GC30654Oxoadipic acid
    CAS: 3184-35-8
    纯度: >98.00% / >96.50% / >97.00%

    Oxoadipic acid是一种必需氨基酸色氨酸和赖氨酸的代谢物，在色氨酸代谢和赖氨酸降解途径中发挥重要作用。

  • GC30658 structure
    GC306584-Methylcatechol
    CAS: 452-86-8
    纯度: >98.00%

    4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.

  • GC30660 structure
    GC306603-Hydroxyisovaleric acid
    CAS: 625-08-1

    An active metabolite of L-leucine

  • GC30661 structure
    GC30661(R)-3-Hydroxyisobutyric acid
    CAS: 1910-47-0

    (R)-3-Hydroxyisobutyricacid是l-缬氨酸和胸腺嘧啶途径中的中间产物，在诊断罕见遗传性代谢疾病3-羟异丁酸和甲基丙二醛脱氢酶缺乏症中起着重要的作用。

  • GC30668 structure
    GC30668Myristic acid
    CAS: 544-63-8
    纯度: >99.50%

    A saturated fatty acid

  • GC30669 structure
    GC306695α-Cholestan-3β-ol (5α-Cholestanol)
    CAS: 80-97-7
    纯度: >98.00%

    5α-Cholestan-3β-ol (5α-Cholestanol) 是一种存在于动物组织、某些植物及微生物中的天然甾醇类化合物，也是胆固醇在体内的重要代谢产物之一。5α-Cholestan-3β-ol常被用于探究胆固醇代谢途径、细胞膜结构功能及相关疾病机制。

  • GC30670 structure
    GC306704-Pyridoxic acid
    CAS: 82-82-6
    纯度: >97.00%

    A pyridoxine metabolite

  • GC30671 structure
    GC306712-Methylpentanedioic acid
    CAS: 617-62-9

    2-Methylglutaric acid (alpha-Methylglutaric acid) is a metabolite of succinic acid, a citric acid cycle intermediate.

  • GC30672 structure
    GC306722,3-Diaminopropionic acid
    CAS: 4033-39-0

    2,3-Diaminopropionicacid是神经毒性氨基酸b-oxalyl-L-a,b-diaminopropionicacid的代谢产物。

  • GC30675 structure
    GC30675Argininic acid
    CAS: 157-07-3

    Argininicacid是一种α-氨基酸，用于蛋白质的生物合成。Argininicacid是一种碱性氨基酸。

  • GC30677 structure
    GC30677Hexadecanedioic acid
    CAS: 505-54-4

    A dicarboxylic fatty acid

  • GC30683 structure
    GC30683Gln-AMS
    CAS: 209543-57-7

    Gln-AMS是一种氨基酰基-tRNA合成酶(AARS)抑制剂，与非核糖体多肽合成酶(NRPS)A结构域结合。

  • GC30684 structure
    GC30684DL-Homocysteine
    CAS: 454-29-5
    纯度: >97.00% / >98.00%

    DL-Homocysteine是一种含硫非必需氨基酸，具有弱神经毒性。

  • GC30686 structure
    GC30686Nervonic acid (Selacholeic acid)
    CAS: 506-37-6
    纯度: >98.00% / >97.00%

    A very long chain fatty acid abundant in sphingomyelin