3-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI))

3-Hydroxypicolinic acid is a matrix substance in matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) applications that has been used in the analysis of oligonucleotides and proteins.^1,2 It has also been used as a complexation agent for metal complexes.³ 3-Hydroxypicolinic acid is an intermediate in the biosynthesis of the antibiotic virginiamycin S₁.⁴

1.Nordhoff, E., Kirpekar, F., Karas, M., et al.Comparison of IR- and UV-matrix-assisted laser desorption/ionization mass spectrometry of oligodeoxynucleotidesNucleic Acids Res.22(13)2460-2465(1994) 2.Karas, M., Bahr, U., Strupat, K., et al.Matrix dependence of metastable fragmentation of glycoproteins in MALDI TOF mass spectrometryAnal. Chem.67(3)675-679(1995) 3.Kiss, E., Petrohán, K., Sanna, D., et al.Solution speciation and spectral studies on oxovanadium(IV) complexes of pyridinecarboxylic acidsPolyhedron19(1)55-61(2000) 4.Reed, J.W., Purvis, M.B., Kingston, D.G.I., et al.Biosynthesis of antibiotics of the virginiamycin family. 7. Stereo- and regiochemical studies on the formation of the 3-hydroxypicolinic acid and pipecolic acid unitsJ. Org. Chem.54(5)1161-1165(1989)