3-hydroxy Lauric acid is a hydroxylated fatty acid that is found in bacteria as well as Pseudosuberites and D. calyx sea sponges.1,2,3,4 It has antifungal activity against a panel of seven fungi (MICs = 10-50 μg/ml).3 3-hydroxy Lauric acid acts as a partial agonist of GPR84 receptors in vitro (EC50 = 5.24 μM).5 [Matreya, LLC. Catalog No. 1731]
1.Kim, M.C., Pak, S.H., Rim, S.G., et al.Luteolibacter arcticus sp. nov., isolated from high Arctic tundra soil, and emended description of the genus LuteolibacterInt. J. Syst. Evol. Microbiol.65(Pt. 6)1922-1928(2015) 2.Panda, S., Bandyopadhyay, P.K., and Chatterjee, S.N.Characterization of Pseudomonas aeruginosa PB112 (JN996498) isolated from infected Labeo bata (Hamilton) by 16S rRNA gene sequence analysis and fatty acid methyl ester (FAME) analysisAfrican J. Biotechnol.12(4)400-405(2013) 3.He, R., Wakimoto, T., Egami, Y., et al.Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine spongeBioorg. Med. Chem. Lett.22(24)7322-7325(2012) 4.Barnathan, G., Kornprobst, J.-M., Doumenq, P., et al.Sponge fatty acids, 5. Characterization of complete series of 2-hydroxy long-chain fatty acids in phospholipids of two Senegalese marine sponges from the family suberitidae: Pseudosuberites sp. and Suberites massaJ. Nat. Prod.56(12)2104-2113(2004) 5.Kaspersen, M.H., Jenkins, L., Dunlop, J., et al.Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4, and GPR84Med. Chem. Commun.8(6)1360-1365(2017)