Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC305134-Butylresorcinol (Butylresorcinol)CAS: 18979-61-8纯度: >98.00%
4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
- GC305642-Hydroxy-4-methoxybenzaldehydeCAS: 673-22-3纯度: >99.50%
A phenol with diverse biological activities
- GC305933-Methyl-2-oxovaleric acidCAS: 1460-34-0纯度: >97.00%
3-Methyl-2-oxovalericacid是一种神经毒素，一种酸性原和一种代谢毒素，它是由支链氨基酸不完整分解产生的异常的代谢物。
- GC30598Citraconic acidCAS: 498-23-7
Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean.
- GC306004-EthylphenolCAS: 123-07-9纯度: >99.50%
4-Ethylphenol (P-Ethylphenol, 4-Hydroxyphenylethane) is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces.
- GC306033-Hydroxyhippuric acidCAS: 1637-75-8纯度: >99.50%
3-Hydroxyhippuricacid是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。
- GC306163-Hydroxybutyric acidCAS: 300-85-6纯度: >95.00% / >98.50%
3-羟基丁酸（3-Hydroxybutyric acid，D-β-hydroxybutyrate，BHB）是一类组蛋白脱乙酰酶（HDAC）的内源性和特异性抑制剂，抑制HDAC1、HDAC3和HDAC4的IC50分别为5.3、2.4和4.5 mM。
- GC30620D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate)CAS: 17629-30-0纯度: >98.00%
A natural trisaccharide
- GC306222-Oxo-3-phenylpropanoic acidCAS: 156-06-9纯度: >99.00%
2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase.
- GC30623(S)-3-Hydroxyisobutyric acidCAS: 2068-83-9纯度: >93.00%
(S)-3-Hydroxyisobutyric acid 是一种重要的器官间代谢物，是 l-缬氨酸和胸腺嘧啶途径的中间体，也是良好的糖异生底物。
- GC306292-Oxobutanoic acidCAS: 600-18-0
2-Oxobutanoic acid (2-Oxobutyrate, 2-ketobutyric acid, 2-oxobutyric acid, alpha-ketobutyric acid, α-ketobutyric acid) is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism.
- GC306304-Guanidinobutanoic acidCAS: 463-00-3纯度: >98.00%
4-Guanidinobutanoate (4-Guanidinobutanoate, gamma-Guanidinobutyric acid, gamma-Guanidinobutanoate) is a normal metabolite present in low concentrations.
- GC30632Dodecanedioic acidCAS: 693-23-2纯度: >98.00%
Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics.
- GC306353-MethylxanthineCAS: 1076-22-8纯度: >99.50%
A cGMP PDE inhibitor and metabolite of theophylline and caffeine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC30513 | 4-Butylresorcinol (Butylresorcinol) | 18979-61-8 | >98.00% | |
4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. | ||||
| GC30564 | 2-Hydroxy-4-methoxybenzaldehyde | 673-22-3 | >99.50% | |
A phenol with diverse biological activities | ||||
| GC30586 | (±) Anabasine | 13078-04-1 | >97.00% / >98.50% | |
(±)Anabasine是一种肌肉松弛剂，可用于外科手术时肌肉松驰。 | ||||
| GC30588 | Protirelin (Synthetic thyrotropin-releasing factor) | 24305-27-9 | - | |
A tropic hormone | ||||
| GC30593 | 3-Methyl-2-oxovaleric acid | 1460-34-0 | >97.00% | |
3-Methyl-2-oxovalericacid是一种神经毒素，一种酸性原和一种代谢毒素，它是由支链氨基酸不完整分解产生的异常的代谢物。 | ||||
| GC30598 | Citraconic acid | 498-23-7 | - | |
Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean. | ||||
| GC30600 | 4-Ethylphenol | 123-07-9 | >99.50% | |
4-Ethylphenol (P-Ethylphenol, 4-Hydroxyphenylethane) is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces. | ||||
| GC30603 | 3-Hydroxyhippuric acid | 1637-75-8 | >99.50% | |
3-Hydroxyhippuricacid是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。 | ||||
| GC30610 | LY 178002 | 107889-32-7 | - | |
LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。 | ||||
| GC30612 | 2-Hydroxyadipic acid | 18294-85-4 | >98.00% | |
A dicarboxylic fatty acid | ||||
| GC30613 | 5-Hydroxydopamine hydrochloride | 5720-26-3 | >95.00% | |
5-Hydroxydopamine是人尿液中天然存在的胺。 | ||||
| GC30615 | Nicotinuric acid | 583-08-4 | - | |
A metabolite of niacin | ||||
| GC30616 | 3-Hydroxybutyric acid | 300-85-6 | >95.00% / >98.50% | |
3-羟基丁酸（3-Hydroxybutyric acid，D-β-hydroxybutyrate，BHB）是一类组蛋白脱乙酰酶（HDAC）的内源性和特异性抑制剂，抑制HDAC1、HDAC3和HDAC4的IC50分别为5.3、2.4和4.5 mM。 | ||||
| GC30617 | Tetradecanoylcarnitine | 25597-07-3 | - | |
Tetradecanoylcarnitine是人体中的肉毒碱，参与长链脂肪酸的β型氧化。 | ||||
| GC30618 | Orotidine | 314-50-1 | >90.00% / >95.00% | |
Orotidine是一种由核糖和orotic acid组成的嘧啶核苷，可在尿液排泄物中发现。 | ||||
| GC30620 | D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate) | 17629-30-0 | >98.00% | |
A natural trisaccharide | ||||
| GC30622 | 2-Oxo-3-phenylpropanoic acid | 156-06-9 | >99.00% | |
2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. | ||||
| GC30623 | (S)-3-Hydroxyisobutyric acid | 2068-83-9 | >93.00% | |
(S)-3-Hydroxyisobutyric acid 是一种重要的器官间代谢物，是 l-缬氨酸和胸腺嘧啶途径的中间体，也是良好的糖异生底物。 | ||||
| GC30624 | L-Alloisoleucine ((3R)-LS-Isoleucine) | 1509-34-8 | >98.00% | |
A branched-chain amino acid | ||||
| GC30629 | 2-Oxobutanoic acid | 600-18-0 | - | |
2-Oxobutanoic acid (2-Oxobutyrate, 2-ketobutyric acid, 2-oxobutyric acid, alpha-ketobutyric acid, α-ketobutyric acid) is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism. | ||||
| GC30630 | 4-Guanidinobutanoic acid | 463-00-3 | >98.00% | |
4-Guanidinobutanoate (4-Guanidinobutanoate, gamma-Guanidinobutyric acid, gamma-Guanidinobutanoate) is a normal metabolite present in low concentrations. | ||||
| GC30631 | Paullinic acid | 17735-94-3 | >95.00% | |
An ω-7 fatty acid | ||||
| GC30632 | Dodecanedioic acid | 693-23-2 | >98.00% | |
Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics. | ||||
| GC30635 | 3-Methylxanthine | 1076-22-8 | >99.50% | |
A cGMP PDE inhibitor and metabolite of theophylline and caffeine | ||||