Orotidine, a pyrimidine nucleoside composed of ribose and orotic acid, can be found in urinary excretion [1]. Orotidine is formed by the irreversible dephosphorylation of orotidine-5′-phosphate [2]. Orotidine is widely used as a novel biomarker for the increased risk of cardiovascular diseases associated with type 2 diabetes [3].
References:
[1] Brown G K, Fox R M, O'Sullivan W J. Alteration of quaternary structural behaviour of an hepatic orotate phosphoribosyltransferase-orotidine-5′-phosphate decarboxylase complex in rats following allopurinol therapy[J]. Biochemical Pharmacology, 1972, 21(18): 2469-2477.
[2] Lotz M, Fallon H J, Smith L H. Excretion of orotic acid and orotidine in heterozygotes of congenital orotic aciduria[J]. Nature, 1963, 197(4863): 194-195.
[3] Shah H S, Moreno L O, Morieri M L, et al. Serum orotidine: A novel biomarker of increased CVD risk in type 2 diabetes discovered through metabolomics studies[J]. Diabetes Care, 2022, 45(8): 1882-1892.
Orotidine是一种由核糖和orotic acid组成的嘧啶核苷，可在尿液排泄物中发现[1]。Orotidine是由orotidine-5′-phosphate经不可逆地去磷酸化形成的[2]。Orotidine被广泛用作与 2 型糖尿病相关的心血管疾病风险增加的新型生物标志物[3]。