Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC30298ButyrylcarnitineCAS: 25576-40-3纯度: >99.00%
Butyrylcarnitine是血浆中的代谢物，是异常脂质和能量代谢的指标，来改善心脏衰竭的诊断和预后。
- GC30304(S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid)CAS: 6168-83-8纯度: >96.00%
(S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid) 是一种正常的人体代谢物，已发现在缓解抑郁症的老年患者中升高。
- GC30332IsovalerylcarnitineCAS: 31023-24-2纯度: >99.00% / >98.00%
Isovalerylcarnitine是L-亮氨酸分解代谢的产物。它增加了钙蛋白酶的活性。
- GC30337Galactose 1-phosphateCAS: 2255-14-3纯度: >98.00%
半乳糖1磷酸是半乳糖-1-磷酸尿苷酰转移酶(GALT)的作用底物,具有细胞毒性,对糖代谢途径中的多种酶有抑制作用.Gal-1-P(1- 16mm;37℃;1h)能刺激大鼠脑Na+,K+-ATP酶。
- GC30343Selenomethionine (Seleno-DL-methionine)CAS: 1464-42-2纯度: >98.00%
硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。
- GC303533-Oxopentanedioic acidCAS: 542-05-2
3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid; 3-Oxoglutaric acid) is an intermediate for organic compound synthesis.
- GC30370Dinoprost (Prostaglandin F2a)CAS: 551-11-1纯度: >99.00% / >96.50%
Dinoprost (Prostaglandin F2a)是一种口服有效的强效前列腺素受体 （FP 受体） 激动剂。Dinoprost刺激子宫肌层活动，放松宫颈，抑制黄体类固醇生成，并通过直接作用诱导黄体溶解。
- GC30395DL-Panthenol (DL-Pantothenol)CAS: 16485-10-2纯度: >98.00%
DL-panthenol (DL-Pantothenol, DL-Pantothenyl alcohol) is a racemic mixture of D and L form of panthenol,a provitamin of B5.
- GC30421Enalapril D5 maleate (MK-421 (D5 maleate))CAS: 349554-02-5
An internal standard for the quantification of enalapril
- GC30427ELN 318463 racemateCAS: 851599-82-1
ELN318463racemate是ELN318463的外消旋体。ELN318463是一种选择性的gamma-secretase抑制剂。
- GC30449Fumaric acidCAS: 110-17-8纯度: >99.00%
Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.
- GC30459Senecionine (Senecionan-11,16-dione, 12-hydroxy-)CAS: 130-01-8纯度: >99.00%
A pyrrolizidine alkaloid with hepatotoxic properties
- GC30472Dehydrocholate sodium (Sodium dehydrocholate)CAS: 145-41-5纯度: >98.00%
Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion.
- GC30505N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride)CAS: 1189971-04-7
N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride) 是氘标记的 N-Desmethyl Clomipramine。
- GC30512Vatiquinone (EPI-743)CAS: 1213269-98-7纯度: >98.00%
A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC30298 | Butyrylcarnitine | 25576-40-3 | >99.00% | |
Butyrylcarnitine是血浆中的代谢物，是异常脂质和能量代谢的指标，来改善心脏衰竭的诊断和预后。 | ||||
| GC30301 | Turanose | 547-25-1 | >98.00% | |
Turanose是一种还原性二糖。 | ||||
| GC30304 | (S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid) | 6168-83-8 | >96.00% | |
(S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid) 是一种正常的人体代谢物，已发现在缓解抑郁症的老年患者中升高。 | ||||
| GC30316 | L-Cystathionine | 56-88-2 | >98.00% | |
An intermediate in cysteine synthesis | ||||
| GC30324 | Mevalonic acid | 150-97-0 | >98.00% | |
甲羟戊酸是从头生物合成途径中胆固醇的前体。 | ||||
| GC30329 | Stearoylcarnitine | 25597-09-5 | >98.00% / >99.00% | |
Stearoylcarnitine是一种脂肪酸酯脂质分子。 | ||||
| GC30332 | Isovalerylcarnitine | 31023-24-2 | >99.00% / >98.00% | |
Isovalerylcarnitine是L-亮氨酸分解代谢的产物。它增加了钙蛋白酶的活性。 | ||||
| GC30333 | Valerylcarnitine | 40225-14-7 | >99.00% | |
Valerylcarnitine是一种内源性短链酰基肉碱代谢物。 | ||||
| GC30334 | NCX 1000 | 401519-96-8 | - | |
NCX1000是一种肝特异性NO供体，它来源于熊去氧胆酸。 | ||||
| GC30337 | Galactose 1-phosphate | 2255-14-3 | >98.00% | |
半乳糖1磷酸是半乳糖-1-磷酸尿苷酰转移酶(GALT)的作用底物,具有细胞毒性,对糖代谢途径中的多种酶有抑制作用.Gal-1-P(1- 16mm;37℃;1h)能刺激大鼠脑Na+,K+-ATP酶。 | ||||
| GC30343 | Selenomethionine (Seleno-DL-methionine) | 1464-42-2 | >98.00% | |
硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。 | ||||
| GC30353 | 3-Oxopentanedioic acid | 542-05-2 | - | |
3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid; 3-Oxoglutaric acid) is an intermediate for organic compound synthesis. | ||||
| GC30354 | D-Pipecolinic acid | 1723-00-8 | - | |
D-Pipecolinicacid是人体液中的一种代谢物。 | ||||
| GC30370 | Dinoprost (Prostaglandin F2a) | 551-11-1 | >99.00% / >96.50% | |
Dinoprost (Prostaglandin F2a)是一种口服有效的强效前列腺素受体 （FP 受体） 激动剂。Dinoprost刺激子宫肌层活动，放松宫颈，抑制黄体类固醇生成，并通过直接作用诱导黄体溶解。 | ||||
| GC30395 | DL-Panthenol (DL-Pantothenol) | 16485-10-2 | >98.00% | |
DL-panthenol (DL-Pantothenol, DL-Pantothenyl alcohol) is a racemic mixture of D and L form of panthenol,a provitamin of B5. | ||||
| GC30421 | Enalapril D5 maleate (MK-421 (D5 maleate)) | 349554-02-5 | - | |
An internal standard for the quantification of enalapril | ||||
| GC30427 | ELN 318463 racemate | 851599-82-1 | - | |
ELN318463racemate是ELN318463的外消旋体。ELN318463是一种选择性的gamma-secretase抑制剂。 | ||||
| GC30438 | RP 70676 | 136609-26-2 | >99.50% | |
RP70676是一种有效的ACAT抑制剂，能够抑制对大鼠和兔子中的ACAT活性，IC50值分别为25和44nM。 | ||||
| GC30449 | Fumaric acid | 110-17-8 | >99.00% | |
Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. | ||||
| GC30459 | Senecionine (Senecionan-11,16-dione, 12-hydroxy-) | 130-01-8 | >99.00% | |
A pyrrolizidine alkaloid with hepatotoxic properties | ||||
| GC30465 | L-Carnosine | 305-84-0 | >99.50% | |
A dipeptide with diverse biological activities | ||||
| GC30472 | Dehydrocholate sodium (Sodium dehydrocholate) | 145-41-5 | >98.00% | |
Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion. | ||||
| GC30505 | N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride) | 1189971-04-7 | - | |
N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride) 是氘标记的 N-Desmethyl Clomipramine。 | ||||
| GC30512 | Vatiquinone (EPI-743) | 1213269-98-7 | >98.00% | |
A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity | ||||