GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC30110 structure
    GC30110Oleic acid (9-cis-Octadecenoic acid)
    CAS: 112-80-1
    纯度: >98.00%

    油酸（9-顺式-十八碳烯酸）是一种单不饱和的Omega-9脂肪酸，存在于植物和动物中。

  • GC30131 structure
    GC30131Leucyl-phenylalanine
    CAS: 3063-05-6
    纯度: >98.00%

    Leucyl-phenylalanine是二肽的有机化合物。

  • GC30136 structure
    GC301362-Ketoglutaric acid
    CAS: 328-50-7

    2-Ketoglutaric acid是一种可逆的酪氨酸酶抑制剂，IC 50 值为15 ± 0.5mM。

  • GC30146 structure
    GC301463,4-Dihydroxymandelic acid
    CAS: 775-01-9
    纯度: >98.00%

    3,4-Dihydroxymandelicacid是去甲肾上腺素的代谢产物。

  • GC30148 structure
    GC30148(S)-b-aminoisobutyric acid
    CAS: 4249-19-8
    纯度: >98.00%

    (S)-b-aminoisobutyric acid是一种经胸腺嘧啶和缬氨酸分解代谢产生的非蛋白质氨基酸。

  • GC30165 structure
    GC30165Perillartine (DL-Perillartine)
    CAS: 30950-27-7
    纯度: >98.50%

    Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.

  • GC30166 structure
    GC30166Coproporphyrin III (Zincphyrin)
    CAS: 14643-66-4
    纯度: >98.50% / >98.00%

    粪卟啉 III (Zincphyrin) (Zincphyrin) 是一种天然存在的卟啉衍生物，主要存在于尿液中。

  • GC30187 structure
    GC30187γ-Glu-Phe (γ-Glutamylphenylalanine)
    CAS: 7432-24-8
    纯度: >98.00%

    γ-Glu-Phe (γ-Glutamylphenylalanine) (γ-Glutamylphenylalanine) 由解淀粉芽孢杆菌 (GBA) 和米曲霉 (GAO) 合成。

  • GC30189 structure
    GC301895-Hydroxymethyl-2-furancarboxylic acid
    CAS: 6338-41-6
    纯度: >97.00%

    A major metabolite of 5-hydroxymethyl-2-furfural

  • GC30192 structure
    GC30192Pyruvic acid (2-Oxopropanoic acid)
    CAS: 127-17-3
    纯度: >98.00%

    Pyruvic acid (2-Oxopropanoic acid)是一种重要的有机化学中间体，也是聚合物的潜在前体。

  • GC30196 structure
    GC30196Maltose monohydrate
    CAS: 6363-53-7
    纯度: >98.00%

    A disaccharide

  • GC30210 structure
    GC30210(R)-3-Hydroxybutanoic acid
    CAS: 625-72-9
    纯度: >98.00%

    (R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途。

  • GC30214 structure
    GC30214Pyruvic aldehyde (~40% in water)
    CAS: 78-98-8
    纯度: 40.26% in water

    Pyruvicaldehyde常被用作有机合成中的一种试剂，一种调味剂以及在鞣革中的应用。

  • GC30215 structure
    GC30215Linoleic acid
    CAS: 60-33-3
    纯度: >98.00% / >99.00%

    An essential ω-6 PUFA

  • GC30219 structure
    GC30219Azelaic acid (Nonanedioic acid)
    CAS: 123-99-9
    纯度: >98.00%

    A dicarboxylic acid with diverse biological activities

  • GC30237 structure
    GC30237Verdiperstat (AZD3241)
    CAS: 890655-80-8
    纯度: >99.50%

    Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.

  • GC30258 structure
    GC30258Menaquinone-4 (Vitamin K2)
    CAS: 863-61-6
    纯度: >98.00%

    Menaquinone-4 (Vitamin K2)是一种含有四个异戊二烯单元的维生素K2，属于萘醌家族。

  • GC30263 structure
    GC30263Glucosamine (D-Glucosamine)
    CAS: 3416-24-8
    纯度: >98.00%

    Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.

  • GC30266 structure
    GC30266L-SelenoMethionine
    CAS: 3211-76-5
    纯度: >99.50% / >98.00%

    L-SelenoMethionine是一种硒氨基酸，作为膳食中的天然成分，约占日常硒摄入量的50%以上。

  • GC30268 structure
    GC30268Maltopentaose (Maltopentose)
    CAS: 34620-76-3
    纯度: >99.00% / >98.00%

    Maltopentaose (Maltopentose)是一种由五个葡萄糖单元通过α-1,4-糖苷键连接而成的寡糖。Maltopentaose是麦芽糊精中最短的低聚糖，能够用于研究α-乳清蛋白的糖化和磷酸化。

  • GC30277 structure
    GC302774',5-Dihydroxyflavone
    CAS: 6665-67-4

    4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.

  • GC30278 structure
    GC30278Cholesteryl oleate
    CAS: 303-43-5
    纯度: >98.00% / >99.00%

    Cholesteryl oleate是动脉粥样硬化斑块中含量最丰富的脂质之一，与动脉粥样硬化的进展相关。

  • GC30281 structure
    GC30281Pyrithioxin (Pyritinol)
    CAS: 1098-97-1

    Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

  • GC30293 structure
    GC30293Arg-AMS
    CAS: 301351-95-1
    纯度: >98.00%

    Arg-AMS是精氨酸tRNA合成酶(arginyltRNAsynthetase)的有效抑制剂，能够和非核糖体多肽合成酶的A结构域紧密结合。