(R)-3-Hydroxybutanoic acid is a polyhydroxybutyrate (PHB) monomer that can be reacted with various hydroxy fatty acids to prepare copolymers with industrial and pharmaceutical uses[1, 2, 3]. (R)-3-Hydroxybutanoic acid is a metabolite obtained from ethyl acetate catalyzed by 3-hydroxybutyrate dehydrogenase[4]. (R)-3-Hydroxybutanoic acid can be used as a nutritional source and a precursor of vitamins, antibiotics and pheromones[5].
References:
[1] Kok F, Hasirci V. Polyhydroxybutyrate and its copolymers: Applications in the medical field[J]. Tissue Engineering and Novel Delivery Systems. 1th ed. Arcel Dekker: New York, NY, USA, 2004: 543-562.
[2] Md. Iqbal N, Amirul A A. Synthesis of P (3HB‐co‐4HB) copolymer with target‐specific 4HB molar fractions using combinations of carbon substrates[J]. Journal of Chemical Technology & Biotechnology, 2014, 89(3): 407-418.
[3] Kundu P P, Nandy A, Mukherjee A, et al. Polyhydroxyalkanoates: Microbial synthesis and applications[J]. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials; CRC Press: Boca Raton, FL, USA, 2015, 11: 10444.
[4] Yañez L, Conejeros R, Vergara-Fernández A, et al. Beyond intracellular accumulation of polyhydroxyalkanoates: chiral hydroxyalkanoic acids and polymer secretion[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8: 248.
[5] Ren Q, Grubelnik A, Hoerler M, et al. Bacterial poly (hydroxyalkanoates) as a source of chiral hydroxyalkanoic acids[J]. Biomacromolecules, 2005, 6(4): 2290-2298.
(R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途[1, 2, 3]。(R)-3-Hydroxybutanoic acid是一种代谢物，由 3-羟基丁酸脱氢酶催化乙酸乙酯获得[4]。(R)-3-Hydroxybutanoic acid能够可作为营养来源和维生素、抗生素和信息素的前体[5]。