GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC19920 structure
    GC19920Ensitrelvir
    CAS: 2647530-73-0
    纯度: >99.00%

    An inhibitor of SARS-CoV-2 M pro

  • GC19926 structure
    GC19926Methyl malonic acid
    CAS: 108-59-8
    纯度: >99.50%

    A dicarboxylic acid and byproduct of propionate catabolism

  • GC19933 structure
    GC19933Leukotriene B4
    CAS: 71160-24-2
    纯度: >95.00%

    A leukotriene involved in inflammation

  • GC19941 structure
    GC19941 DL-Leucic Acid
    CAS: 498-36-2
    纯度: ≥98%
  • GC20007 structure
    GC20007Ginsenoside CK
    CAS: 39262-14-1
    纯度: >98.00%

    Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。

  • GC20062 structure
    GC20062trans-3'-Hydroxycotinine
    CAS: 34834-67-8
    纯度: >98.00%

    A metabolite of nicotine

  • GC20109 structure
    GC20109Cefotiam hexetil hydrochloride
    CAS: 95789-30-3

    Cefotiam hexetil hydrochloride 是可口服的第三代头孢菌素，是 cefotiam 的前药，但无抗菌作用。Cefotiam 是一种抗生素。

  • GC25117 structure
    GC25117Azvudine
    CAS: 1011529-10-4

    Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

  • GC25188 structure
    GC25188Calcium 2-oxoglutarate
    CAS: 71686-01-6

    Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.

  • GC25337 structure
    GC25337D-Carnitine hydrochloride
    CAS: 10017-44-4

    D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.

  • GC25536 structure
    GC25536JHU395
    CAS: 2079938-92-2

    JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.

  • GC25723 structure
    GC25723Perindopril L-Arginine
    CAS: 612548-45-5

    Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.

  • GC25726 structure
    GC25726PF-05221304
    CAS: 1370448-25-1

    PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

  • GC25727 structure
    GC25727PF-06446846
    CAS: 1632250-49-7

    PF-06446846具有口服活性的前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）翻译抑制剂。

  • GC26017 structure
    GC26017UK-371804 HCl
    CAS: 256476-36-5

    UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

  • GC26092 structure
    GC26092Z-LEHD-FMK TFA
    CAS: 524746-03-0

    Z-LEHD-FMK TFA是一种不可逆的caspase-9抑制剂。

  • GC26233 structure
    GC26233Docosahexaenoic Acid-d5
    CAS: 1197205-71-2
    纯度: >99.00%

    Docosahexaenoic acid-d5 (DHA-d5) is intended for use as an internal standard for the quantification of DHA (Item No. 90310) by GC- or LC-MS.

  • GC26385 structure
    GC26385CL-82198
    CAS: 307002-71-7
    纯度: >98.00%

    CL-82198 是一个选择性的 MMP-13 抑制剂。

  • GC30014 structure
    GC30014Elamipretide (MTP-131)
    CAS: 736992-21-5
    纯度: >98.00%

    Elamipretide (MTP-131) 作为一种水溶性四肽，可以增强细胞 ATP 合成，从而改善电子传输并减少 ROS 的形成。

  • GC30027 structure
    GC30027S-(+)-Marmesin ((+)-Marmesin)
    CAS: 13849-08-6
    纯度: >98.00%

    A coumarin with anticancer activity

  • GC30044 structure
    GC30044L-Ornithine ((S)-2,5-Diaminopentanoic acid)
    CAS: 70-26-8
    纯度: >98.00% / >95.00% / >99.50%

    L-ornithine ((S)-2,5-Diaminopentanoic acid)是一种天然存在的非蛋白质氨基酸，在人体的尿素循环中发挥重要作用。

  • GC30047 structure
    GC30047Olumacostat glasaretil
    CAS: 1261491-89-7
    纯度: >98.50%

    Olumacostatglasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。

  • GC30048 structure
    GC30048Pantethine (D-Pantethine)
    CAS: 16816-67-4
    纯度: >98.00%

    Pantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides.

  • GC30103 structure
    GC30103Lecithin
    CAS: 8002-43-5
    纯度: >98.00% / >98.50%

    A sphingolipid