Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC46779 Acequinocyl
灭螨醌
A naphthoquinone acaricide
GC46769 Abametapir
55'-二甲基-2,2-联吡啶
A building block and an insecticide
GC46755 9(S)-HODE-13C18
(+)-α-Dimorphecolic Acid
A neuropeptide with diverse biological activities
GC46753 9(S),12(S),13(S)-TriHOME
(-)-Pinellic Acid, 9S,12S,13S-Pinellic Acid
An oxylipin
GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
7(S),17(S)hydroxy DPA
A metabolite of DPA with anti-inflammatory properties
GC46679 5(S)-HETE-d8
5(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 5-HETE
GC46599 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)
DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3
A neuropeptide with diverse biological activities
GC46583 3-Amino-2,6-Piperidinedione
3-氨基-2,6-哌啶二酮
An active metabolite of (±)-thalidomide
GC46539 2-Chloroadenine
2-氯-6-氨基嘌呤
A heterocyclic building block
GC46508 2',2'-Difluoro-2'-deoxyuridine
2'-脱氧-2',2'-二氟尿嘧啶核苷
An active metabolite of gemcitabine
GC46488 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-PC
1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphatidylcholine, PC(16:0/22:6), 16:0/22:6-PC, PDPC
A phospholipid
GC46482 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC
1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC
A lysophospholipid
GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
GC46457 17(R)-Resolvin D1-d5
Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5
A neuropeptide with diverse biological activities
GC46451 16F16 A PDI inhibitor
GC46442 15(S)-HETE-d8
15(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15(S)-HETE
GC46441 15(S)-HEPE-d5
15S-Hydroxyeicosapentaenoic Acid-d5
A neuropeptide with diverse biological activities
GC46436 13-OxoODE-d3
13KODEd3
A neuropeptide with diverse biological activities
GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
GC46418 12-oxo-13-HOME An oxylipin
GC46416 12-epi Leukotriene B4-d4
12epi LTB4d4
A neuropeptide with diverse biological activities
GC46387 1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid
GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
GC46284 (±)-Cotinine-d3
氘代甲基可替宁,(±)-Cotinine-d3; (Rac)-NIH-10498-d3
An internal standard for the quantification of cotinine
GC61354 Trimethylamine N-oxide dihydrate
二水氧化三甲胺
A metabolite of choline, phosphatidylcholine, and L-carnitine
GC61353 Trimethoprim N-oxide
Trimethoprim 1-N-oxide
TrimethoprimN-oxide(Trimethoprim1-N-oxide)属于人尿代谢物。TrimethoprimN-oxide是通过氧化嘧啶环中的氮原子生成的。TrimethoprimN-oxide主要由CYP1A2在人肝微粒体中形成。
GC61350 Tridecanedioic acid
十三烷二酸
1,11-Undecanedicarboxylic acid (Tridecanedioic acid, Brassylic acid, Brassilic acid) is an unusual odd-numbered dicarboxylic acid that appears in the urines of children with neonatal adrenoleukodystrophy and Zellweger syndrome, as an additional marker of these peroxisomal disorders.
GC61343 trans-2-Hexadecenoyl-L-carnitine
反-2-十六碳烯酰肉碱
trans-2-Hexadecenoyl-L-carnitine是一种内源性代谢产物，存在于尿液中。
GC61325 Tetradecanedioic acid
十四烷二酸
Tetradecanedioic acid (Tetradecanedicarboxylate) is a C14 dicarboxylic acid.
GC61323 Tetrac
四碘甲状腺乙酸,Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid
Tetrac(Tetraiodothyroaceticacid)，L-甲状腺素(T4)的天然衍生物，是甲状腺素整合素受体拮抗剂。Tetrac阻断T4和3,5,3'-triiodo-L-thyronine(T3)在整联蛋白αvβ3上甲状腺激素的细胞表面受体处的作用。Tetra具有抗血管生成和抗肿瘤活性。
GC61318 Tectol
乌楠酚
Tectol，从Lippiasidoides中分离，对人白血病细胞株HL60和CEM具有显著的抑制作用。Tectol是一种farnesyltransferase(FTase)抑制剂，在人和布氏锥虫的IC50分别为2.09和1.73μM。Tectol抑制耐药恶性疟原虫(FcB1)，IC50为3.44μM。
GC61310 SY-640 SY-640是乙酰胺衍生物，具有有效的保肝作用。SY-640可减轻痤疮丙酸杆菌和脂多糖诱导的小鼠肝损伤。
GC61298 Sulcatone
6-甲基-5-庚烯-2-酮,6-Methyl-5-hepten-2-one
Sulcatone是一种内源性代谢产物。
GC61274 Senecionine acetate
O-Acetylsenecionine
Senecionineacetate(O-Acetylsenecionine)是吡咯烷核生物碱。Senecionineacetate通过使游离巯基失活来抑制线粒体和线粒体区室中Ca2+的螯合。
GC61182 Phosphoramide mustard (cyclohexanamine)
NSC 69945, PMC
An alkylating agent and active metabolite of cyclophosphamide
GC61181 Phenylpropiolic acid
苯丙炔酸
Phenylpropiolicacid是一种内源性代谢产物。
GC61180 Phenidone
菲尼酮
Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
GC61165 Paeoniflorgenin
芍药苷元
Paeoniflorgenin是Paeoniflorin的去糖基化代谢产物。
GC61164 Oxytetracycline hydrochloride
盐酸土霉素
A broad-spectrum antibiotic
GC61158 ONO-5334 ONO-5334是一种强效、选择性和口服活性的组织蛋白酶K(cathepsinK)抑制剂，对人、兔和大鼠组织蛋白酶K的作用值分别为0.10nM、0.049nM和0.85nM。ONO-5334是一种有效的抗SAR-COV-2病毒活性的抗病毒化合物，其EC50值为500nM。ONO-5334有潜力用于骨质疏松症以及COVID-19的相关研究。
GC61150 O-Desmethylangolensin
O-DMA
A phytoestrogen and an active metabolite of diadzein
GC61147 O-desmethyl Mebeverine acid
美贝维林去甲基苯甲酸,Mebeverine metabolite O-desmethyl Mebeverine acid
A metabolite of mebeverine
GC61145 Octadecanedioic acid
十八烷二酸
Octadecanedioicacid是一种内源性代谢物，一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。
GC61144 Octadecanal
十八烷醛
Octadecanal是一种长链醛，存在于大腿和胸部肌肉中。
GC61137 Nordoxepin D3 hydrochloride
Desmethyldoxepin-d3 hydrochloride
NordoxepinD3hydrochloride(DesmethyldoxepinD3hydrochloride)是Nordoxepinhydrochloride的氘代物。Nordoxepinhydrochloride是Doxepinhydrochloride的活性代谢产物，Doxepinhydrochloride具有口服活性和抗抑郁作用。
GC61130 NHC-triphosphate
NHC-triphosphate是NHC的活性胞内磷酸盐代谢物(intracellularmetabolite)，以三磷酸盐的形式存在。NHC-triphosphate是病毒聚合酶(viralpolymerase)的弱底物替代物，会被并入HCV复制子RNA中。
GC61115 N-Desethyl Oxybutynin D5 hydrochloride N-DesethylOxybutyninD5hydrochloride是N-DesethylOxybutyninhydrochloride的氘代物。N-DesethylOxybutynin是Oxybutynin的活性代谢产物。Oxybutynin是一种抗胆碱能药，抑制电压依赖型K+通道。
GC61107 N-Acetyl-L-glutamic acid
N-乙酰-L-谷氨酸
N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
GC61105 N4-Acetylcytidine
N4-乙酰基胞苷
A catabolite of cytidine
GC61103 N,N,O-Tridesmethylvenlafaxine
1-2-氨基-1-(4-羟苯基)乙基环己醇
N,N,O-Tridesmethylvenlafaxine是一种内源性代谢产物。