GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC19483 structure
    GC19483MS-PPOH
    CAS: 206052-02-0

    A potent, selective inhibitor of microsomal CYP450 epoxidase activity

  • GC19495 structure
    GC19495DL-Folinic Acid (calcium salt)
    CAS: 1492-18-8
    纯度: >99.00%

    A reduced folic acid

  • GC19520 structure
    GC19520Cysteine Protease inhibitor
    CAS: 921625-62-9
    纯度: >95.00%

    半胱氨酸蛋白酶抑制剂是半胱氨酸蛋白酶的抑制剂。

  • GC19523 structure
    GC19523Sivelestat sodium tetrahydrate
    CAS: 201677-61-4
    纯度: >98.00% / >99.00%

    An inhibitor of neutrophil elastase

  • GC19528 structure
    GC195281,4-Benzoquinone
    CAS: 106-51-4
    纯度: >99.00%

    A toxic metabolite of benzene

  • GC19539 structure
    GC195392-Pyrrolidinone
    CAS: 616-45-5
    纯度: >99.00%
  • GC19563 structure
    GC19563D-Lyxose
    CAS: 1114-34-7
    纯度: >99.00% / >98.00%

    D-Lyxose 是一种内源性代谢物。

  • GC19569 structure
    GC19569Hydroquinone
    CAS: 123-31-9
    纯度: >99.00%
  • GC19572 structure
    GC19572Catechol
    CAS: 120-80-9
    纯度: 99.50%

    A polyphenol

  • GC19584 structure
    GC19584Alkaline Phosphatase
    CAS: 9001-78-9
    纯度: BA-38units/mg protein (37℃,pH9.8) / BA-38units/mg protein (37℃,pH9.8)2

    10-50units/mg protein(37℃,pH 9.8)

  • GC19608 structure
    GC19608Putrescine
    CAS: 110-60-1
    纯度: >98.00%

    Putrescine腐胺(多胺、亚精胺和精胺)是一种低分子量的有机阳离子，它们在细胞生长、细胞分化、调节酶活性、调节离子通道以及控制DNA和蛋白质合成等方面具有重要作用。

  • GC19626 structure
    GC19626Cyclic AMP
    CAS: 60-92-4
    纯度: >99.50% / >99.00%

    环磷酸腺苷（Cyclic AMP; cAMP）是三磷酸腺苷的衍生物，是第一个被鉴定出的第二信使，将信号从受体传播到下游途径。

  • GC19630 structure
    GC19630Adenosine 2′-monophosphate
    CAS: 130-49-4

    腺苷 &2#8242;-一磷酸 (2'-AMP) 被细胞外 2',3'-CAMP 转化。

  • GC19704 structure
    GC19704Flavone
    CAS: 525-82-6
    纯度: >99.50%

    A polyphenolic flavonoid

  • GC19706 structure
    GC19706Propacetamol hydrochloride
    CAS: 66532-86-3

    A prodrug form of acetaminophen

  • GC19711 structure
    GC19711N-(2-furoyl)glycine
    CAS: 5657-19-2
    纯度: >99.50% / >98.00%

    N-(2-furoyl)glycine 是人体的一种尿液代谢物，是咖啡消费的推定生物标志物。

  • GC19715 structure
    GC197152-hydroxyisobutyrate
    CAS: 594-61-6
    纯度: >97.00%

    2-羟基异丁酸是一种内源性代谢物。

  • GC19716 structure
    GC197163-methyl-2-oxobutyrate
    CAS: 3715-29-5

    3-methyl-2-oxobutyrate 是大肠杆菌中泛酸的前体。

  • GC19717 structure
    GC197171,6-anhydroglucose
    CAS: 498-07-7

    1,6-脱水-β-D-吡喃葡萄糖用于制备具有重要生物学意义和结构多样的产品，例如利福霉素 S、茚满霉素、血栓烷 B2、(+)-生物素、河豚毒素、醌、大环内酯类抗生素和改性糖。它在大气化学研究中用作生物质燃烧的化学示踪剂，特别是在空气中的颗粒物方面，并且有助于生产生物乙醇。

  • GC19718 structure
    GC19718Inosinic acid (IMP)
    CAS: 131-99-7
    纯度: >98.00%

    Inosinic acid (IMP) 是一种在嘌呤代谢中起核心作用的核苷酸，也是重要的食品风味增强剂。

  • GC19749 structure
    GC19749Maleamic acid
    CAS: 557-24-4

    马来酸是一种内源性代谢物。

  • GC19750 structure
    GC19750alpha-L-Rhamnose
    CAS: 3615-41-6

    Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level

  • GC19766 structure
    GC19766Heparin sodium salt (MW 15kDa)
    CAS: 9041-08-1
    纯度: >99.50%

    肝素钠盐（MW 15kDa）（Sodium heparin (MW 15kDa)）是肝素的聚合物，分子量为15kDa。

  • GC19839 structure
    GC19839Trypsin inhibitor(soybean) (≥4000 BAEE Units/mg)
    CAS: 9035-81-8
    纯度: {{1-8}BA-≥4000 BAEE Units/mg / {9}BA-4000 BAEE Units/mg / {10}BA-4120 BAEE Units/mg} / {11}BA-4230BAEE U/mg}

    Trypsin inhibitor(soybean)是一种胰蛋白酶(trypsin)抑制剂，IC 50 为19 µM，也可以抑制胰凝乳蛋白酶，IC 50 为14.3µM。