GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC19257 structure
    GC19257MX69
    CAS: 1005264-47-0
    纯度: >99.50%

    An inhibitor of the MDM2 protein and XIAP RNA interaction

  • GC19261 structure
    GC19261ND-630 (Firsocostat)
    CAS: 1434635-54-7
    纯度: >98.00%

    ND-630 (Firsocostat)是一种乙酰辅酶A羧化酶(ACC)抑制剂，可抑制ACC1（IC 50 =2.1nM）和ACC2（IC 50 =6.1nM）的活性。

  • GC19268 structure
    GC19268NVP-HDM201
    CAS: 1448867-41-1
    纯度: >98.00%

    NVP-HDM201 (NVP-HDM201) 是一种有效的、口服生物利用度高且高度特异性的 p53-MDM2 相互作用抑制剂。

  • GC19284 structure
    GC19284PF-05175157
    CAS: 1301214-47-0
    纯度: >98.00%

    An inhibitor of ACC1 and 2

  • GC19285 structure
    GC19285PF-06282999
    CAS: 1435467-37-0
    纯度: >99.00%

    A myeloperoxidase inhibitor

  • GC19290 structure
    GC19290PF-3084014
    CAS: 1290543-63-3
    纯度: >98.00%

    An inhibitor of γ-secretase

  • GC19312 structure
    GC19312RO8994
    CAS: 1309684-94-3
    纯度: >99.00%

    An inhibitor of MDM2-p53 interaction

  • GC19347 structure
    GC19347TAPI-2
    CAS: 187034-31-7
    纯度: >99.00%

    An inhibitor of TACE and MMPs

  • GC19353 structure
    GC19353TFAP
    CAS: 1011244-68-0
    纯度: >99.50%

    A selective COX-1 inhibitor

  • GC19358 structure
    GC19358TM5275 sodium
    CAS: 1103926-82-4
    纯度: >98.00%

    A PAI-1 inhibitor

  • GC19380 structure
    GC19380Vorasidenib
    CAS: 1644545-52-7
    纯度: >99.50%

    An inhibitor of mutant IDH1 and IDH2

  • GC19383 structure
    GC19383WNK463
    CAS: 2012607-27-9
    纯度: >99.00%

    WNK463是一种口服WNK激酶抑制剂，对WNK1、WNK2、WNK3和WNK4的IC50值分别为5 nM、1 nM、6 nM和9 nM 。

  • GC19385 structure
    GC19385XMD16-5
    CAS: 1345098-78-3
    纯度: >98.50%

    A TNK2 inhibitor

  • GC19387 structure
    GC19387XMD8-87
    CAS: 1234480-46-6
    纯度: >98.50%

    A selective TNK2 inhibitor

  • GC19403 structure
    GC19403Protoporphyrin IX
    CAS: 553-12-8
    纯度: >95.00% / >98.00%

    Protoporphyrin IX是一种在血红素生物合成途径中的重要的卟啉类化合物，常被用于光动力疗法中。

  • GC19439 structure
    GC19439Nudifloramide
    CAS: 701-44-0
    纯度: >98.00%

    A metabolite of niacin via nicotinamide

  • GC19442 structure
    GC1944215-Acetyldeoxy Nivalenol
    CAS: 88337-96-6

    A natural mycotoxin

  • GC19444 structure
    GC19444(±)20-HDHA
    CAS: 90906-41-5
    纯度: >98.00%

    An autoxidation product of DHA and potential marker of oxidative stress

  • GC19460 structure
    GC194609(S)-HODE
    CAS: 73543-67-6
    纯度: >98.00%

    A lipoxygenase product of linoleic acid

  • GC19462 structure
    GC1946213(R)-HODE
    CAS: 10219-69-9
    纯度: >98.00%

    An enantiomer of 13(S)-HODE

  • GC19463 structure
    GC1946313(S)-HODE
    CAS: 29623-28-7
    纯度: >98.00%

    Product of 15-LO metabolism of linoleic acid

  • GC19474 structure
    GC1947413(S)-HpODE
    CAS: 33964-75-9
    纯度: >95.00%

    Stimulates EGF-dependent mitogenesis and tyrosine phosphorylation

  • GC19477 structure
    GC19477Lanosterol
    CAS: 79-63-0
    纯度: >98.00%

    Lanosterol是胆固醇生物合成过程中的一种三萜类中间体，能够诱导HMG CoA还原酶的泛素化和降解。

  • GC19478 structure
    GC19478Estetrol
    CAS: 15183-37-6

    A naturally occurring estrogen