GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC18831 structure
    GC18831Tolmetin β-D-Glucuronide
    CAS: 71595-19-2

    A major phase II metabolite of tolmetin

  • GC18832 structure
    GC18832Conglobatin
    CAS: 72263-05-9

    An Hsp90 inhibitor

  • GC18835 structure
    GC18835Leukotriene A4 methyl ester
    CAS: 73466-12-3
    纯度: >97.00%

    A stable form of LTA 4

  • GC18845 structure
    GC18845Leukotriene F4
    CAS: 83851-42-7
    纯度: >97.00%

    A CysLT produced in vitro from LTE 4

  • GC18869 structure
    GC18869Deoxyenterocin
    CAS: 108605-51-2

    A bacterial metabolite with diverse biological activities

  • GC18877 structure
    GC18877CAY10606
    CAS: 1159576-98-3

    Inhibitor of 5-lipoxygenase

  • GC18959 structure
    GC18959PF-06424439
    CAS: 1469284-79-4
    纯度: >99.50% / >98.00%

    PF-06424439是一种高效、口服生物可利用的选择性二酰基甘油酰基转移酶2（DGAT2）小分子抑制剂，IC 50 值为14nM。

  • GC18961 structure
    GC18961Pyripyropene A
    CAS: 147444-03-9
    纯度: >95.00%

    A potent ACAT2-selective inhibitor

  • GC18992 structure
    GC18992Duclauxin
    CAS: 1732-37-2

    An antitumor agent

  • GC19012 structure
    GC19012(R)-GNE-140
    CAS: 2003234-63-5
    纯度: >99.00%

    (R)-GNE-140是一种具有口服活性的乳酸脱氢酶A（LDHA）抑制剂，(R)-GNE-140对LDHA（IC 50 =3nM）和LDHB（IC 50 =5nM）的抑制活性均比S型异构体的高。

  • GC19021 structure
    GC19021Adjudin
    CAS: 252025-52-8
    纯度: >98.00%

    A derivative of lonidamine

  • GC19052 structure
    GC19052AZD7986
    CAS: 1802148-05-5
    纯度: >99.00%

    An inhibitor of DPP-1

  • GC19059 structure
    GC19059BAY-1436032
    CAS: 1803274-65-8
    纯度: >99.00%

    An inhibitor of mutant IDH1

  • GC19088 structure
    GC19088CC122
    CAS: 1015474-32-4
    纯度: >99.50%

    A pleiotropic pathway modifier with anticancer activity

  • GC19094 structure
    GC19094CCT251236
    CAS: 1693731-40-6
    纯度: >99.00%

    An inhibitor of Hsf1-mediated transcription

  • GC19120 structure
    GC19120DBPR108
    CAS: 1186426-66-3
    纯度: >99.50%

    DBPR108 是一种有效的、选择性的、口服生物可利用的二肽衍生的 DPP4 抑制剂，IC50 为 15 nM。对 DDP8 和 DPP9 无抑制作用。

  • GC19121 structure
    GC19121Debio 0932
    CAS: 1061318-81-7
    纯度: >98.00%

    An Hsp90 inhibitor

  • GC19134 structure
    GC19134beta-D-(-)-Arabinose
    CAS: 10323-20-3
    纯度: >98.00%

    A monosaccharide

  • GC19138 structure
    GC19138CTPI-2
    CAS: 68003-38-3
    纯度: >98.50%

    A mitochondrial citrate transporter inhibitor

  • GC19165 structure
    GC19165Glecaprevir
    CAS: 1365970-03-1
    纯度: >98.00%

    An HCV NS3/4A protease inhibitor

  • GC19171 structure
    GC19171Glutaminase C-IN-1
    CAS: 311795-38-7
    纯度: >98.00%

    Glutaminase C-IN-1是一种小分子，可作为谷氨酰胺酶的变构抑制剂，阻断谷氨酰胺分解并影响谷氨酰胺代谢。

  • GC19188 structure
    GC19188HA15
    CAS: 1609402-14-3
    纯度: >99.50%

    HA15是一种特异性靶向BiP/GRP78/HSPA5的分子，可结合并抑制其ATPase活性，导致BiP与PERK、IRE1α和ATF6分离，从而引发内质网应激。

  • GC19215 structure
    GC19215KRIBB11
    CAS: 342639-96-7
    纯度: >98.00%

    An Hsf1 inhibitor

  • GC19221 structure
    GC19221Leucomethylene blue Mesylate
    CAS: 1236208-20-0
    纯度: >98.00%

    An inhibitor of tau aggregation