Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC18616MMP-8 Inhibitor ICAS: 236403-25-1纯度: >95.00% / >98.00%
MMP-8 Inhibitor I是一种强效的基质金属蛋白酶-8（MMP-8）抑制剂，但口服生物利用度较低。
- GC186283-Methylcrotonyl GlycineCAS: 33008-07-0纯度: >99.00%
A metabolite with diverse biological activities
- GC18659Ribavirin 5'-monophosphate (lithium salt)CAS: 66983-94-6
A potent, broad-spectrum antiviral agent
- GC18663Leukotriene C4CAS: 72025-60-6纯度: >97.00% / >95.00%
The parent cysteinyl leukotriene produced by LTC 4 synthase catalyzed conjugation of glutathione to LTA 4
- GC18791Prostaglandin H1CAS: 52589-22-7纯度: >95.00%
The precursor to all 1-series prostaglandins and thromboxanes
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18608 | MMP-2/MMP-9 Inhibitor II | 193807-60-2 | - | |
A dual inhibitor of MMP-2 and MMP-9 | ||||
| GC18612 | MMP-9/MMP-13 Inhibitor I | 204140-01-2 | - | |
An MMP inhibitor | ||||
| GC18616 | MMP-8 Inhibitor I | 236403-25-1 | >95.00% / >98.00% | |
MMP-8 Inhibitor I是一种强效的基质金属蛋白酶-8（MMP-8）抑制剂，但口服生物利用度较低。 | ||||
| GC18621 | Antimycin A2 | 27220-57-1 | - | |
An active component of the antimycin A antibiotic complex | ||||
| GC18622 | (2'S)-Nicotine-1-oxide | 2820-55-5 | - | |
A nicotine metabolite | ||||
| GC18628 | 3-Methylcrotonyl Glycine | 33008-07-0 | >99.00% | |
A metabolite with diverse biological activities | ||||
| GC18632 | 6-hydroxy Bexarotene | 368451-07-4 | - | |
An oxidative metabolite of bexarotene | ||||
| GC18641 | Ferutinin | 41743-44-6 | >98.00% | |
An ERα agonist | ||||
| GC18646 | Myristelaidic Acid | 50286-30-1 | >98.00% | |
A monounsaturated ω-5 fatty acid | ||||
| GC18654 | 8-hydroxy Loxapine | 61443-77-4 | - | |
A loxapine metabolite | ||||
| GC18659 | Ribavirin 5'-monophosphate (lithium salt) | 66983-94-6 | - | |
A potent, broad-spectrum antiviral agent | ||||
| GC18663 | Leukotriene C4 | 72025-60-6 | >97.00% / >95.00% | |
The parent cysteinyl leukotriene produced by LTC 4 synthase catalyzed conjugation of glutathione to LTA 4 | ||||
| GC18680 | Lipoxin A4 methyl ester | 97643-35-1 | >95.00% | |
A lipid soluble, prodrug of LXA 4 | ||||
| GC18681 | Lipoxin B4 | 98049-69-5 | >95.00% | |
A positional isomer of LXA 4 | ||||
| GC18688 | CAY10589 | 1077626-52-8 | - | |
Dual Inhibitor of mPGES-1 and 5-LO | ||||
| GC18699 | JCP174 | 126062-19-9 | - | |
An inhibitor of palmitoyl protein thioesterase-1 | ||||
| GC18702 | Propiverine N-oxide (hydrochloride) | 1329509-71-8 | - | |
An active propiverine metabolite | ||||
| GC18705 | ML-210 | 1360705-96-9 | >99.50% / >98.00% | |
ML-210是一种前体药物，能够选择性共价抑制GPX4，EC 50 值为30nM。 | ||||
| GC18706 | SR 9186 | 1361414-26-7 | - | |
A selective inhibitor of CYP3A4 | ||||
| GC18709 | D-NMMA (acetate) | 137694-75-8 | - | |
A control compound for studying NOS inhibition | ||||
| GC18728 | CJ-13610 | 179420-17-8 | - | |
An inhibitor of 5-LO | ||||
| GC18791 | Prostaglandin H1 | 52589-22-7 | >95.00% | |
The precursor to all 1-series prostaglandins and thromboxanes | ||||
| GC18799 | CPD77 | 2144491-78-9 | >99.50% | |
CPD77 是 X77 的外消旋体。 | ||||
| GC18817 | 3β-hydroxy-5-Cholestenoic Acid | 6561-58-6 | - | |
An active cholesterol metabolite | ||||