Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC18522Phosphatidylserines (sodium salt)CAS: 383908-63-2纯度: >95.00%
A mixture of phosphatidylserines isolated from soy
- GC185394-Hydroxyretinoic acid (4-HRA)CAS: 66592-72-1纯度: >98.00%
4-Hydroxyretinoic acid (4-HRA)是一种天然存在的，由全反式视黄酸（ATRA）经细胞色素P450酶代谢生成的主要代谢产物。
- GC18552Lipoxin A4CAS: 89663-86-5纯度: >95.00%
Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes
- GC18567β-hydroxy Pyruvic AcidCAS: 1113-60-6纯度: >98.00%
A metabolite in the process of photorespiration
- GC18569Propofol β-D-GlucuronideCAS: 114991-26-3纯度: >98.00%
Propofol β-D-Glucuronide是丙泊酚的代谢产物，被广泛用作鉴定动物体内丙泊酚代谢状态的标志物。
- GC18583D-α-Hydroxyglutaric AcidCAS: 13095-47-1纯度: >98.00%
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18425 | 4-hydroxy Atorvastatin lactone | 163217-70-7 | - | |
A metabolite of atorvastatin | ||||
| GC18437 | Alternariol monomethyl ether | 23452-05-3 | - | |
A mycotoxin | ||||
| GC18439 | Doxorubicinone | 24385-10-2 | >95.00% | |
A metabolite of doxorubicin | ||||
| GC18452 | 3,4-Dichloroisocoumarin | 51050-59-0 | >99.50% | |
A serine protease inhibitor | ||||
| GC18455 | Digoxigenin Monodigitoxoside | 5352-63-6 | - | |
A Na + /K + -ATPase inhibitor | ||||
| GC18466 | 5,6-epoxy-13-cis Retinoic Acid | 81444-57-7 | - | |
A metabolite of 13-cis retinoic acid | ||||
| GC18471 | DG-051 | 929915-58-2 | >99.50% | |
An LTA 4 hydrolase inhibitor | ||||
| GC18476 | Biotin-VAD-FMK | 1135688-15-1 | >98.00% | |
A biotin-conjugated pan-caspase inhibitor | ||||
| GC18480 | CAY10649 | 1272519-89-7 | - | |
A direct inhibitor of 5-LO product formation | ||||
| GC18510 | Siccanin | 22733-60-4 | - | |
An inhibitor of mitochondrial complex II | ||||
| GC18517 | Diapocynin | 29799-22-2 | - | |
An inhibitor of NADPH-oxidase | ||||
| GC18522 | Phosphatidylserines (sodium salt) | 383908-63-2 | >95.00% | |
A mixture of phosphatidylserines isolated from soy | ||||
| GC18527 | 4'-hydroxy Flurbiprofen | 52807-12-2 | - | |
A major active metabolite of flurbiprofen | ||||
| GC18539 | 4-Hydroxyretinoic acid (4-HRA) | 66592-72-1 | >98.00% | |
4-Hydroxyretinoic acid (4-HRA)是一种天然存在的，由全反式视黄酸（ATRA）经细胞色素P450酶代谢生成的主要代谢产物。 | ||||
| GC18542 | 5,6-dihydro-5-Fluorouracil | 696-06-0 | >95.00% | |
A metabolite of 5-FU | ||||
| GC18544 | 8-dehydro Cholesterol | 70741-38-7 | >95.00% | |
An isomer of 7-DHC | ||||
| GC18552 | Lipoxin A4 | 89663-86-5 | >95.00% | |
Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes | ||||
| GC18561 | TZ9 | 1002789-86-7 | >99.50% | |
A Rad6B inhibitor | ||||
| GC18567 | β-hydroxy Pyruvic Acid | 1113-60-6 | >98.00% | |
A metabolite in the process of photorespiration | ||||
| GC18569 | Propofol β-D-Glucuronide | 114991-26-3 | >98.00% | |
Propofol β-D-Glucuronide是丙泊酚的代谢产物，被广泛用作鉴定动物体内丙泊酚代谢状态的标志物。 | ||||
| GC18580 | B355252 | 1261576-81-1 | - | |
A neuroprotective agent | ||||
| GC18582 | 5'-hydroxy Meloxicam | 130262-92-9 | - | |
A metabolite of meloxicam | ||||
| GC18583 | D-α-Hydroxyglutaric Acid | 13095-47-1 | >98.00% | |
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。 | ||||
| GC18596 | (±)-2-propyl-4-Pentenoic Acid | 1575-72-0 | >98.00% | |
A metabolite of valproic acid | ||||