Propofol β-D-Glucuronide is a metabolite of propofol and is widely used as a marker to identify the metabolic status of propofol in animals [1]. Propofol β-D-Glucuronide exhibits limited antioxidant capacity in rat liver microsomes[2]. Propofol β-D-Glucuronide is widely used as a standard substance to develop novel liquid chromatography-electrospray tandem mass spectrometry detection methods in analytical chemistry[3].
References:
[1] Yan Z, Ha L, Chen H, et al. Sleep deprivation alters hepatic UGT1A9 and propofol metabolism in mice[J]. Biochemical Pharmacology, 2025, 232: 116713.
[2] Boisset S, Steghens J P, Favetta P, et al. Relative antioxidant capacities of propofol and its main metabolites[J]. Archives of toxicology, 2004, 78(11): 635-642.
[3] Sørensen L K, Hasselstrøm J B. Simultaneous determination of propofol and its glucuronide in whole blood by liquid chromatography–electrospray tandem mass spectrometry and the influence of sample storage conditions on the reliability of the test results[J]. Journal of pharmaceutical and biomedical analysis, 2015, 109: 158-163.
Propofol β-D-Glucuronide是丙泊酚的代谢产物，被广泛用作鉴定动物体内丙泊酚代谢状态的标志物[1]。Propofol β-D-Glucuronide在大鼠肝微粒体中表现出有限的抗氧化能力[2]。Propofol β-D-Glucuronide可作为标准品用于分析化学中开发新型液相色谱-电喷雾串联质谱检测方法[3]。