Dinotefuran is a neonicotinoid insecticide.1 It is an agonist of nicotinic acetylcholine receptors (nAChRs), inducing inward currents in isolated American cockroach (P. americana) neurons with an EC50 value of 7.6 ?M. Dinotefuran, alone or in combination with the metabolic inhibitors piperonyl butoxide or propargyl propyl benzenephosphonate (NIA), induces mortality in adult P. americana.2 It is lethal to insecticide-sensitive or -resistant strains of A. gambiae, C. quinquefasciatus, and A. aegypti in larval (LC50s = 0.14-0.44 mg/L) and adult (LD50s = 0.18-31.16 ng/mg) bioassays.3 Dinotefuran has been found in a variety of commercial foodstuffs, including rice, cucumber, milk, egg, and pork samples, as well as in water samples from freshwater streams.4,5 Formulations containing dinotefuran have been used in the agricultural and veterinary control of insect infestations.
1.Tan, J., Galligan, J.J., and Hollingworth, R.M.Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neuronsNeurotoxicology28(4)829-842(2007) 2.Kiriyama, K., and Nishimura, K.Structural effects of dinotefuran and analogues in insecticidal and neural activitiesPest Manag. Sci.58(7)669-676(2002) 3.Corbel, V., Duchon, S., Zaim, M., et al.Dinotefuran: A potential neonicotinoid insecticide against resistant mosquitoesJ. Med. Entomol.41(4)712-717(2004) 4.Zhang, Y., Wu, X., Duan, T., et al.Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal-derived foods, soil, and waterJ. Sep. Sci.41(14)2913-2923(2018) 5.Hladik, M.L., and Kolpin, D.W.First national-scale reconnaissance of neonicotinoid insecticides in streams across the USAEnviron. Chem.1312-20(2016)