2-Phenylacetamide is a metabolite of L-phenylalanine .1,2 It increases the proliferation of MCF-7 cells, an effect that can be blocked by the estrogen receptor (ER) antagonist ICI 182780 .3 It also increases the levels of luteinizing hormone and estrogen and the expression of estrogen receptor α (ERα) and ERβ in the uterus of immature female mice. Urinary levels of 2-phenylacetamide are increased in male obese patients compared with non-obese males.1
1.Yu, H.-T., Fu, X.-Y., Xu, B., et al.Untargeted metabolomics approach (UPLC-Q-TOF-MS) explores the biomarkers of serum and urine in overweight/obese young menAsia Pac. J. Clin. Nutr.27(5)1067-1076(2018) 2.Guan, Y., Hu, W., Xu, Y., et al.Metabolomics and physiological analyses validates previous findings on the mechanism of response to wounding stress of different intensities in broccoliFood Res. Int.140110058(2021) 3.Zeng, M., Li, M., Li, M., et al.2-Phenylacetamide isolated from the seeds of Lepidium apetalum and its estrogen-like effects in vitro and in vivoMolecules23(9)2293(2018)