Thymopentin is a pentapeptide fragment of thymopoietin.1 It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 ?M. Thymopentin (1 ?g/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).2 It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.1 Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.3
1.Goldstein, G., Scheid, M.P., Boyse, E.A., et al.A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietinScience204(4399)1309-1310(1979) 2.Duchateau, J., Servais, G., Cooman, R., et al.In vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte culturesSurv. Immunol. Res.4(1)116-124(1985) 3.Lau, C.Y., Wang, E.Y., and Goldstein, G.Studies of thymopoietin pentapeptide (TP5) on experimental tumorsCell Immunol.66(2)217-232(1982)