| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 10mg | ¥135.00 | 现货 | 1 | |
| 50mg | ¥405.00 | 现货 | 1 | |
| 100mg | ¥675.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥589.00 | 现货 | 1 |
Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
[1] P D Smith, et al. Drug Intell Clin Pharm. 1987 May;21(5):417-21. [2] J R López-López, et al. Mol Pharmacol. 1998 Feb;53(2):330-9.
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Animal experiment: |
Rats[2]8-week-old male spf Wistar rats are used. Rats are anaesthetized with Thiobarbiturate inactin (BYK, 100 mg/kg, i.p.). The interaction of the ventilatory response to hypoxia and an intermittent (2 min on, 1 min break) low-dose (10 μg/kg per min) and high-dose (80 μg/kg per min) infusion of S9581 or Almitrine is tested in control and chronically hypoxic rats. S9581 or Almitrine is infused intravenously (100 μg/ mL). Inspired oxygen levels were controlled by passing oxygen-nitrogen mixtures across the tracheal port at a flow rate of 3-41 min-1[2]. |
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References: [1]. López-López JR, et al. Effects of Almitrine bismesylate on the ionic currents of chemoreceptor cells from the carotid body. Mol Pharmacol. 1998 Feb;53(2):330-9. |
