GlpBio

UDP-GlcNAc Disodium Salt

目录号: GC33787纯度: >98.00%同义词: 5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt
UDP-GlcNAc Disodium Salt由己糖胺生物合成途径（HBP）生成，并作为几种重要生物分子的前体，如糖胺聚糖，这些是哺乳动物蛋白质糖基化反应的必需底物。
UDP-GlcNAc Disodium Salt
Cas No.: 91183-98-1
规格价格库存数量操作
1mg¥213.00现货
1
5mg¥560.00现货
1
10mg¥952.00现货
1
25mg¥1,680.00现货
1
100mg¥2,920.00现货
1
500mg¥8,892.00现货
1
1g¥15,314.00现货
1
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文献被引

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产品描述 Description

UDP-GlcNAc Disodium Salt is produced by the hexosamine biosynthesis pathway (HBP)[1]and acts as a precursor for several important biomolecules like glycosaminoglycans, which is an essential substrate for protein glycosylation reactions in mammals[2]. UDP-GlcNAc Disodium Salt is a donor substrate for glycosyltransferases, enzymes that attach sugar moieties to proteins, lipids, and nucleic acids, which is important in cellular signaling, adhesion, and immune responses[3]. UDP-GlcNAc Disodium Salt is primarily used in research on glycobiology[4] and the study of metabolic diseases, including diabetes[5] and cancer[6].

References:
[1]. Paneque A, Fortus H, Zheng J, et al. The Hexosamine Biosynthesis Pathway: Regulation and Function. Genes (Basel). 2023 Apr 18;14(4):933. doi: 10.3390/genes14040933. PMID: 37107691; PMCID: PMC10138107.
[2]. Ruegenberg S, Horn M, Pichlo C, et al. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020 Feb 4;11(1):687. doi: 10.1038/s41467-020-14524-5. PMID: 32019926; PMCID: PMC7000685.
[3]. Yang X, Qian K. Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465. doi: 10.1038/nrm.2017.22. Epub 2017 May 10. PMID: 28488703; PMCID: PMC5667541.
[4]. van Wijk XM, Thijssen VL, Lawrence R, et al. Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis. ACS Chem Biol. 2013 Oct 18;8(10):2331-8. doi: 10.1021/cb4004332. Epub 2013 Sep 3. PMID: 23972127; PMCID: PMC3821560.
[5]. Slawson C, Copeland RJ, Hart GW. O-GlcNAc signaling: a metabolic link between diabetes and cancer? Trends Biochem Sci. 2010 Oct;35(10):547-55. doi: 10.1016/j.tibs.2010.04.005. Epub 2010 May 11. PMID: 20466550; PMCID: PMC2949529.
[6]. Pan X, Wilson M, Mirbahai L, McConville C, Arvanitis TN, Griffin JL, Kauppinen RA, Peet AC. In vitro metabonomic study detects increases in UDP-GlcNAc and UDP-GalNAc, as early phase markers of cisplatin treatment response in brain tumor cells. J Proteome Res. 2011 Aug 5;10(8):3493-500. doi: 10.1021/pr200114v. Epub 2011 Jun 27. PMID: 21644796.

UDP-GlcNAc Disodium Salt由己糖胺生物合成途径（HBP）生成[1]，并作为几种重要生物分子的前体，如糖胺聚糖，这些是哺乳动物蛋白质糖基化反应的必需底物[2]。UDP-GlcNAc Disodium Salt是糖基转移酶的供体底物，这些酶将糖基附着到蛋白质、脂类和核酸上，这在细胞信号传导、粘附和免疫反应中起重要作用[3]。UDP-GlcNAc Disodium Salt主要用于糖生物学研究[4]以及包括糖尿病[5]和癌症[6]在内的疾病的研究。

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
91183-98-1
同义词
5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt
SMILES
O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)NC(C)=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+]
分子式
C17H25N3Na2O17P2
分子量
651.32 g/mol
溶解性
PBS (pH 7.2): 10 mg/ml
保存条件
Store at -20°C,protect from light,unstable in solution, ready to use.
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol