Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC18105EnterostatinCAS: 117830-79-2纯度: >99.50% / >98.00%
A pentapeptide involved in the regulation of food intake
- GC18147Tretinoin (Aberela)CAS: 302-79-4纯度: >99.50% / >98.00%
Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。
- GC18188MPP+ IodideCAS: 36913-39-0纯度: >98.00%
MPP+ Iodide（1-methyl-4-phenylpyridinium iodide）是神经毒素 MPTP 的一种有毒代谢物，通过选择性破坏黑质中的多巴胺能神经元，在体外模型中成功诱导了帕金森样综合征。
- GC18232Prostaglandin D2CAS: 41598-07-6纯度: >98.00% / >99.00%
A major prostaglandin produced by mast cells
- GC183899-cis RetinalCAS: 514-85-2纯度: >98.00% / >95.00%
9-cis Retinal是一种天然视黄醇，由顺式视黄醇脱氢酶（cRDH）氧化9-cis Retinol生成，能够结合视黄醇结合蛋白（CRBP）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18105 | Enterostatin | 117830-79-2 | >99.50% / >98.00% | |
A pentapeptide involved in the regulation of food intake | ||||
| GC18136 | BH3I-1 | 300817-68-9 | >98.00% | |
An inhibitor of anti-apoptotic Bcl-2 proteins | ||||
| GC18147 | Tretinoin (Aberela) | 302-79-4 | >99.50% / >98.00% | |
Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。 | ||||
| GC18170 | ML-346 | 100872-83-1 | >98.00% | |
An activator of the heat shock response | ||||
| GC18173 | TM5441 | 1190221-43-2 | >98.00% | |
TM5441是一种具有口服生物利用度的纤溶酶原激活物抑制剂-1（PAI-1）抑制剂，其IC₅₀值介于13.9至51.1μM之间，并能在多种人类癌细胞系中诱导内源性凋亡。 | ||||
| GC18183 | Nifurtimox | 23256-30-6 | >99.50% / >98.00% | |
An antiprotozoal agent | ||||
| GC18188 | MPP+ Iodide | 36913-39-0 | >98.00% | |
MPP+ Iodide（1-methyl-4-phenylpyridinium iodide）是神经毒素 MPTP 的一种有毒代谢物，通过选择性破坏黑质中的多巴胺能神经元，在体外模型中成功诱导了帕金森样综合征。 | ||||
| GC18194 | 4-Epidoxycycline | 6543-77-7 | - | |
A metabolite of doxycycline | ||||
| GC18219 | 6-hydroxy Warfarin | 17834-02-5 | >98.00% | |
A phase I metabolite of (+)-warfarin | ||||
| GC18224 | Cholesterol α-Linolenate | 2545-22-4 | >98.00% | |
A cholesterol ester | ||||
| GC18232 | Prostaglandin D2 | 41598-07-6 | >98.00% / >99.00% | |
A major prostaglandin produced by mast cells | ||||
| GC18249 | NQ301 | 130089-98-4 | >98.50% | |
A naphthoquinone with diverse biological activities | ||||
| GC18256 | PF-06281355 | 1435467-38-1 | >99.50% | |
A myeloperoxidase inhibitor | ||||
| GC18274 | Amiprofos-methyl | 36001-88-4 | - | |
An herbicide | ||||
| GC18289 | Lathosterol | 80-99-9 | >95.00% | |
An intermediate in the biosynthesis of cholesterol | ||||
| GC18315 | Calpain Inhibitor VI | 190274-53-4 | >95.00% | |
A calpain and cathepsin inhibitor | ||||
| GC18335 | 6β-hydroxy Dexamethasone | 55879-47-5 | - | |
A metabolite of dexamethasone | ||||
| GC18359 | 4-Epianhydrochlortetracycline (hydrochloride) | 158018-53-2 | - | |
An inhibitor of MMP-9 | ||||
| GC18389 | 9-cis Retinal | 514-85-2 | >98.00% / >95.00% | |
9-cis Retinal是一种天然视黄醇，由顺式视黄醇脱氢酶（cRDH）氧化9-cis Retinol生成，能够结合视黄醇结合蛋白（CRBP）。 | ||||
| GC18398 | Sitostanol | 83-45-4 | >99.00% / >98.00% | |
Sitostanol是常见植物甾醇sitosterol的一种代谢物，能降低胆固醇的胶束溶解度。 | ||||
| GC18408 | BML-278 | 120533-76-8 | - | |
An activator of SIRT1, SIRT2, and SIRT3 | ||||
| GC18417 | 4-hydroxy Xylazine | 145356-32-7 | >98.00% / >97.50% | |
A xylazine metabolite | ||||
| GC18423 | IDH305 | 1628805-46-8 | >98.00% | |
A potent and selective inhibitor of mutant IDH1 | ||||
| GC18424 | SBC-110736 | 1629166-02-4 | >99.50% | |
A PCSK9 inhibitor | ||||