Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC17709NelfinavirCAS: 159989-64-7纯度: >98.50% / >99.00%
Nelfinavir是一种选择性的、非肽类的HIV-1蛋白酶竞争性抑制剂。Nelfinavir对HIV-1病毒株显示出良好的体外活性。
- GC17726OtamixabanCAS: 193153-04-7纯度: >98.50%
Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂，可有效抑制游离和凝血酶原结合的 fXa。
- GC17823L-Cysteinesulfinic acidCAS: 1115-65-7纯度: >98.00%
L-半胱氨酸亚磺酸是几种大鼠代谢型谷氨酸受体 (mGluR) 的有效激动剂，对 mGluR1、mGluR5、mGluR2、mGluR4、mGluR6 和 mGluR8 的 pEC50 分别为 3.92、4.6、3.9、2.7、4.0 和 3.94 .
- GC17978Vitamin D2 (Ergocalciferol)CAS: 50-14-6纯度: >98.00%
A vitamin produced in fungi and invertebrates
- GC18002Vitamin B12CAS: 68-19-9纯度: >99.50% / >98.00%
Vitamin B12是一种含钴的水溶性维生素，作为甲硫氨酸合酶和L-甲基丙二酰辅酶A变位酶的辅助因子。
- GC18016SalicylanilideCAS: 87-17-2纯度: >99.00%
Salicylanilide 具有广泛的生物活性，包括抗病毒效力，可通过靶向 HIV-1 整合酶或逆转录酶来抑制 HIV 病毒。
- GC18089Nordihydroguaiaretic acidCAS: 500-38-9纯度: >95% / >97.00% / >98.00%
A non-selective LO inhibitor
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC17701 | Clemizole hydrochloride | 1163-36-6 | >99.50% | |
An antihistamine and TRPC5 channel blocker | ||||
| GC17702 | K-Ras(G12C) inhibitor 9 | 1469337-91-4 | - | |
An allosteric inhibitor of oncogenic K-Ras(G12C) | ||||
| GC17709 | Nelfinavir | 159989-64-7 | >98.50% / >99.00% | |
Nelfinavir是一种选择性的、非肽类的HIV-1蛋白酶竞争性抑制剂。Nelfinavir对HIV-1病毒株显示出良好的体外活性。 | ||||
| GC17711 | PPACKII (trifluoroacetate salt) | 649748-23-2 | - | |
An irreversible inhibitor of kallikreins | ||||
| GC17726 | Otamixaban | 193153-04-7 | >98.50% | |
Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂，可有效抑制游离和凝血酶原结合的 fXa。 | ||||
| GC17738 | MMP-2 Inhibitor I | 10335-69-0 | >98.00% | |
A selective MMP-2 inhibitor | ||||
| GC17751 | MKT 077 | 147366-41-4 | >98.00% | |
An Hsp70 inhibitor | ||||
| GC17777 | Palmitoylethanolamide | 544-31-0 | >98.00% | |
An endogenous cannabinoid | ||||
| GC17801 | PYZD-4409 | 423148-78-1 | >98.00% | |
PYZD-4409 是泛素激活酶 UBA1 的特异性抑制剂，IC50 为 20 μM（无细胞酶测定）。 PYZD-4409 在恶性细胞中诱导细胞死亡并优先抑制原发性急性髓细胞白血病细胞的克隆形成。 | ||||
| GC17809 | GSK864 | 1816331-66-4 | >99.00% / >98.00% | |
GSK864是一种突变型isocitrate dehydrogenases 1 (mIDH1)抑制剂，对IDH1 R132H、IDH1 R132C及WT IDH1的EC 50 值分别为0.16μM、0.10μM和2.74μM。 | ||||
| GC17814 | L-Sorbose | 87-79-6 | >95.00% | |
A monosaccharide | ||||
| GC17823 | L-Cysteinesulfinic acid | 1115-65-7 | >98.00% | |
L-半胱氨酸亚磺酸是几种大鼠代谢型谷氨酸受体 (mGluR) 的有效激动剂，对 mGluR1、mGluR5、mGluR2、mGluR4、mGluR6 和 mGluR8 的 pEC50 分别为 3.92、4.6、3.9、2.7、4.0 和 3.94 . | ||||
| GC17829 | 1-Hexadecanol | 36653-82-4 | - | |
鲸蜡醇（1-Hexadecanol）是一种合成的固体脂肪醇和非离子表面活性剂，是一种亲脂性底物，鲸蜡醇在药物制剂中用作乳化剂。 | ||||
| GC17901 | Tamoxifen | 10540-29-1 | >98.00% / >99.00% | |
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。 | ||||
| GC17902 | Inosine | 58-63-9 | >99.00% / >98.00% | |
A purine nucleoside | ||||
| GC17937 | 2-MPPA | 254737-29-6 | >98.00% | |
2-MPPA (GPI-5693) 是一种具有口服活性的选择性谷氨酸羧肽酶 II (GCP II; PSMA) 抑制剂，IC50 为 90 nM。 | ||||
| GC17941 | Benazepril HCl | 86541-74-4 | >99.50% / >98.00% | |
A prodrug of benazeprilat | ||||
| GC17942 | Darunavir Ethanolate | 635728-49-3 | >99.50% | |
An HIV-1 protease inhibitor | ||||
| GC17978 | Vitamin D2 (Ergocalciferol) | 50-14-6 | >98.00% | |
A vitamin produced in fungi and invertebrates | ||||
| GC17985 | Chenodeoxycholic Acid | 474-25-9 | >98.00% | |
A primary bile acid | ||||
| GC18002 | Vitamin B12 | 68-19-9 | >99.50% / >98.00% | |
Vitamin B12是一种含钴的水溶性维生素，作为甲硫氨酸合酶和L-甲基丙二酰辅酶A变位酶的辅助因子。 | ||||
| GC18016 | Salicylanilide | 87-17-2 | >99.00% | |
Salicylanilide 具有广泛的生物活性，包括抗病毒效力，可通过靶向 HIV-1 整合酶或逆转录酶来抑制 HIV 病毒。 | ||||
| GC18075 | Erythritol | 149-32-6 | - | |
赤藓糖醇是一种糖醇，天然存在于各种食物中（例如。 | ||||
| GC18089 | Nordihydroguaiaretic acid | 500-38-9 | >95% / >97.00% / >98.00% | |
A non-selective LO inhibitor | ||||