GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC17287 structure
    GC17287Iberin
    CAS: 505-44-2
    纯度: >98.00%

    A natural isothiocyanate

  • GC17342 structure
    GC17342Beauvericin
    CAS: 26048-05-5
    纯度: >95.00% / >98.00%

    白僵菌素（Beauvericin）是一种环状十六缩酚肽霉菌毒素，是酰基辅酶 A：胆固醇酰基转移酶 1（ACAT1）的有效抑制剂，参与多种肿瘤相关途径。

  • GC17347 structure
    GC17347Alprostadil
    CAS: 745-65-3
    纯度: >98.00%

    前列地尔Alprostadil作为前列腺素受体配体,对小鼠EP3、EP4、EP2、IP和EP1的结合亲和Kis分别为1.1 nM、2.1 nM、10 nM、33 nM和36 nM。

  • GC17362 structure
    GC17362Metolazone
    CAS: 17560-51-9
    纯度: >99.50%

    A thiazide-like diuretic

  • GC17393 structure
    GC17393Pyridoxine HCl
    CAS: 58-56-0
    纯度: >99.50%

    Pyridoxine HCl是维生素B6的盐酸盐形式，具有抗氧化剂的作用。

  • GC17398 structure
    GC17398Cholesterol
    CAS: 57-88-5
    纯度: >99.00%

    A sterol

  • GC17417 structure
    GC17417SBC-115076
    CAS: 489415-96-5
    纯度: >98.00%

    An inhibitor of PCSK9 action

  • GC17423 structure
    GC17423TS 155-2
    CAS: 1314486-37-7
    纯度: >95.00%

    An antihypertensive antibiotic

  • GC17425 structure
    GC17425Sodium Tauroursodeoxycholate (TUDC)
    CAS: 35807-85-3
    纯度: >98.00%

    Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达，例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。

  • GC17436 structure
    GC174362'-Deoxycytidine-5'-monophosphoric acid
    CAS: 1032-65-1
    纯度: >99.00%

    A deoxyribonucleotide

  • GC17456 structure
    GC17456NMDA (N-Methyl-D-aspartic acid)
    CAS: 6384-92-5
    纯度: >98.00%

    An excitatory neurotransmitter

  • GC17470 structure
    GC17470(-)-Cotinine
    CAS: 486-56-6
    纯度: >98.00%

    A major metabolite of nicotine

  • GC17478 structure
    GC174782-Deoxycytidine
    CAS: 951-77-9
    纯度: >98.00%

    A deoxyribonucleoside

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    纯度: >99.50%

    A DDP-4 inhibitor

  • GC17498 structure
    GC17498L-Glutamine
    CAS: 56-85-9
    纯度: >99.00% / >98.00%

    A conditionally essential amino acid

  • GC17521 structure
    GC17521N-acetyl D-galactosamine
    CAS: 1811-31-0
    纯度: >95.00% / >98.00%

    An amino sugar derivative of galactose

  • GC17558 structure
    GC17558Adenosine 5'-triphosphate disodium salt hydrate
    CAS: 34369-07-8
    纯度: >98.00%

    Adenosine 5'-triphosphate disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) 是体内能量储存和代谢的核心成分，提供代谢能量以驱动代谢泵，并作为细胞中的辅酶。

  • GC17566 structure
    GC1756624, 25-Dihydroxy VD3
    CAS: 40013-87-4
    纯度: >98.00%

    24, 25-二羟基VD3是一种与1,25-二羟基维生素D3密切相关的化合物，是维生素D3的活性形式。

  • GC17591 structure
    GC17591D-erythro-Sphingosine (synthetic)
    CAS: 123-78-4
    纯度: >98.00%

    D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。

  • GC17642 structure
    GC17642JMV 390-1
    CAS: 148473-36-3

    JMV 390-1 (Compound 6a) 是一种有效的多肽酶抑制剂。

  • GC17658 structure
    GC17658Guggulsterone
    CAS: 95975-55-6
    纯度: >99.50%

    Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。

  • GC17667 structure
    GC17667Cilazapril Monohydrate
    CAS: 92077-78-6
    纯度: >99.00%

    A prodrug form of cilazaprilat

  • GC17676 structure
    GC17676Nafamostat
    CAS: 81525-10-2

    Nafamostat是一种合成的丝氨酸蛋白酶抑制剂。

  • GC17693 structure
    GC17693Enniatin B
    CAS: 917-13-5

    A natural inhibitor of Pdr5p in yeast