Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC16971β-Nicotinamide mononucleotideCAS: 1094-61-7纯度: >98.00% / >99.00%
β-烟酰胺单核苷酸是烟酰胺磷酸核糖转移酶（NAMPT）反应的产物，也是关键的NAD+中间体。
- GC17114MK-5172 potassium saltCAS: 1206524-86-8纯度: >99.00%
MK-5172钾盐（MK-5172钾盐）是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂，具有跨基因型和耐药变体的广泛活性，Kis为0.01 nM（gt1b），0.01 nM（gt1a），0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC16768 | Phosphoramidon Disodium Salt | 164204-38-0 | - | |
An inhibitor of NEP and NEP2 | ||||
| GC16772 | Cortisone acetate | 50-04-4 | >98.00% | |
A synthetic glucocorticoid | ||||
| GC16775 | Rotenone | 83-79-4 | >99.50% | |
Rotenone是一种线粒体电子传递链复合物 I 抑制剂，可通过增强线粒体活性氧的产生来诱导细胞凋亡。 | ||||
| GC16812 | 3-Methylglutaric acid | 626-51-7 | - | |
A metabolite of L-leucine | ||||
| GC16823 | Enniatin Complex | 11113-62-5 | - | |
A complex mixture of ionophores | ||||
| GC16829 | Arphamenine B (hemisulfate) | 144110-38-3 | - | |
An inhibitor of aminopeptidase B | ||||
| GC16831 | Agmatine sulfate | 2482-00-0 | >98.00% | |
A polyamine metabolite | ||||
| GC16871 | Perindopril | 82834-16-0 | - | |
An orally active ACE inhibitor | ||||
| GC16949 | Guanine | 73-40-5 | >98.00% | |
A purine base | ||||
| GC16971 | β-Nicotinamide mononucleotide | 1094-61-7 | >98.00% / >99.00% | |
β-烟酰胺单核苷酸是烟酰胺磷酸核糖转移酶（NAMPT）反应的产物，也是关键的NAD+中间体。 | ||||
| GC17012 | MK3102 | 1226781-44-7 | >99.00% | |
MK3102 (Omarigliptin)是一种新型的每周一次的二肽基肽酶-4 (DPP-4)抑制剂(IC50: 2.2 nM)，用于治疗2型糖尿病。 | ||||
| GC17017 | Racecadotril | 81110-73-8 | >98.50% | |
An enkephalinase inhibitor | ||||
| GC17034 | Temocapril HCl | 110221-44-8 | >99.50% | |
A prodrug form of temocaprilat | ||||
| GC17057 | Lithocholic Acid | 434-13-9 | >98.00% / >99.50% | |
A toxic secondary bile acid | ||||
| GC17114 | MK-5172 potassium salt | 1206524-86-8 | >99.00% | |
MK-5172钾盐（MK-5172钾盐）是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂，具有跨基因型和耐药变体的广泛活性，Kis为0.01 nM（gt1b），0.01 nM（gt1a），0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。 | ||||
| GC17117 | CGS 35066 | 261619-50-5 | - | |
endothelin-converting enzyme (ECE) inhibitor | ||||
| GC17170 | gamma-Glu-Cys | 636-58-8 | >98.00% / >95.00% / >98.50% | |
gamma-Glu-Cys是由谷胱甘肽合成酶产生的二肽。 | ||||
| GC17210 | 17-AAG Hydrochloride | 911710-03-7 | - | |
Hsp90 inhibitor,geldanamycin analogue | ||||
| GC17216 | NAD+ | 53-84-9 | >99.50% / >98.00% | |
NAD+是一种转递氢离子的辅酶，参与许多酶促反应，由核糖基烟酰胺5'-二磷酸通过焦磷酸键与5'-磷酸腺苷偶联组成。 | ||||
| GC17228 | Thiabendazole | 148-79-8 | >99.50% | |
A broad-spectrum anthelmintic | ||||
| GC17242 | (-)-epigallocatechin | 970-74-1 | >98.00% | |
(-)-epigallocatechin是绿茶中的一种主要多酚类化合物，具有抗氧化特性。 | ||||
| GC17245 | MMP-13 Inhibitor | 544678-85-5 | >98.00% | |
A selective MMP-13 inhibitor | ||||
| GC17252 | Dextrose (D-glucose) | 50-99-7 | >99.00% | |
A monosaccharide | ||||
| GC17278 | Adenine sulfate | 321-30-2 | - | |
A purine base | ||||