gamma-Glu-Cys is a dipeptide produced by glutathione synthetase [1]. gamma-Glu-Cys can promote the secretion of anti-inflammatory cytokines (such as IL-10) while reducing the levels of pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-1β) [2]. gamma-Glu-Cys is used to improve the prevention and treatment of oxidative stress, inflammatory responses, and neurodegenerative diseases [3].
References:
[1]. Grant C M, MacIver F H, Dawes I W. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine[J]. Molecular biology of the cell, 1997, 8(9): 1699-1707.
[2]. Braidy N, Zarka M, Jugder B E, et al. The precursor to glutathione (GSH), γ-Glutamylcysteine (GGC), can ameliorate oxidative damage and neuroinflammation induced by Aβ40 oligomers in human astrocytes[J]. Frontiers in aging neuroscience, 2019, 11: 177.
[3]. Skutkova H, Babula P, Stiborova M, et al. Structure, polymorphisms and electrochemistry of mammalian metallothioneins–a review[J]. International Journal of Electrochemical Science, 2012, 7(12): 12415-12431.
gamma-Glu-Cys是由谷胱甘肽合成酶产生的二肽 [1]。gamma-Glu-Cys可以促进抗炎细胞因子（如IL-10）的分泌，同时降低促炎细胞因子（如TNF-α、IL-6和IL-1β）的水平 [2]。gamma-Glu-Cys用于改善氧化应激、炎症反应和神经退行性疾病的预防和治疗 [3]。